NCT03742856UnknownNot Applicable
A Multi-omics Study on the Invasiveness of Epithelial Ovarian Cancer
Lei Li1 site in 1 country80 target enrollmentStarted: November 10, 2018Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Frequencies of somatic driving mutations
Study Overview
Brief Summary
This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the invasiveness and tumorigenesis of EOC.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Confirmed primary epithelial ovarian cancer
- •Signed an approved informed consents
- •Feasible for biopsy
Exclusion Criteria
- •Not meeting all of the inclusion criteria
Outcomes
Primary Outcomes
Frequencies of somatic driving mutations
Time Frame: Two years
The differences of frequencies of somatic driving mutations will be compared between patients of different FIGO stages and different pathological subtypes.
Secondary Outcomes
- Progression-free survival(Five years)
- Frequencies of alteration of RNA expression(Two years)
- Frequencies of alteration of protein expression and signal pathway(Two years)
Investigators
Lei Li
Professor
Peking Union Medical College Hospital
Study Sites (1)
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