MedPath

Evaluation of Intravascular Irradiation of Blood in Children With Sleep Bruxism

Phase 2
Conditions
Sleep Bruxism, Childhood
Sleep Bruxism
Interventions
Radiation: Placebo Intravascular Irradiation of Blood (ILIB)
Radiation: Intravascular Irradiation of Blood (ILIB)
Procedure: Orofacial Myofunctional Therapy
Registration Number
NCT05301452
Lead Sponsor
University of Nove de Julho
Brief Summary

Background: The objective of this study will be to evaluate the effect of Intravascular Irradiation of Blood (ILIB) combined with myofunctional exercises for sleep bruxism in pediatrics. Methods: This study will be a randomized controlled clinical trial. A triage of individuals between 4 and 17 years old with a diagnosis of sleep bruxism will be carried out at the clinic of the Catholic University of Uruguay, and in a private office referred by different private care centers. The selected participants will be evaluated before and after treatment by means of questionnaires on bruxism, sleep quality and nocturnal oxygen saturation measurement. For this, 46 patients with sleep bruxism will be recruited, who will be divided into 2 groups: control group (CG), which will undergo an application of placebo ILIB and an orofacial myofunctional therapy (MFT) exercise protocol; and na ILIB group, which will carry out an active application of ILIB and an exercise protocol, this being once a week for 8 weeks. The laser treatment (808 nm) will be performed twice a week for 8 weeks. The values will be tested for normality by the Kolmogorov-Smirnov test. For the comparison between the groups, T-test will be carried out, considering a level of significance of 0.5% (p\<0.05). Discussion: Although local photobiomodulation (PBM), acupuncture PBM and physiotherapy have been studied in the treatment of bruxism, this is the first study to evaluate the effect of ILIB combined with myofunctional exercises for sleep bruxism in pediatrics.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
46
Inclusion Criteria
  • in the mixed dentition phase (permanent incisors and first molars erupted);
  • adolescents with an established permanent dentition.
Exclusion Criteria
  • People with dental caries;
  • Those taking medications, such as inflammatory agents, muscle relaxants, corticosteroids, anticonvulsants, and antidepressants;
  • Those with chronic diseases that affect muscles or motor coordination, and those who do not cooperate during the evaluation will be excluded from the study;
  • Children with cerebral palsy;
  • Patients whose guardians do not sign the informed consent or the user does not sign the assent.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Control GroupPlacebo Intravascular Irradiation of Blood (ILIB)This group will receive an application of placebo ILIB and an orofacial myofunctional therapy (MFT) exercise protocol.
Control GroupOrofacial Myofunctional TherapyThis group will receive an application of placebo ILIB and an orofacial myofunctional therapy (MFT) exercise protocol.
ILIB GroupIntravascular Irradiation of Blood (ILIB)This group will receive an application of ILIB and an orofacial myofunctional therapy (MFT) exercise protocol.
ILIB GroupOrofacial Myofunctional TherapyThis group will receive an application of ILIB and an orofacial myofunctional therapy (MFT) exercise protocol.
Primary Outcome Measures
NameTimeMethod
Changes in OximetryBaseline and 8 weeks of treatment.

A portable pulse oximeter that includes Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry under motion and low perfusion conditions will be used. Nocturnal oximetry will be performed prior to treatment and post treatment. The parents or guardians of the minor will be trained.

Secondary Outcome Measures
NameTimeMethod
Changes in ChewingBaseline and 8 weeks of treatment.

A clinical evaluation will be carried out by a speech therapist specialized in the area of Orofacial Motricity, to check for possible improvement in chewing. For this, the gnatodynamometer, test that allows to measure the force of the occlusion, will be used.

Changes in BreathingBaseline and 8 weeks of treatment.

A clinical evaluation will be carried out by a speech therapist specialized in the area of Orofacial Motricity, to check for possible improvement in breathing. It is the respiratory characterization from the taking of air, which explains the anatomical and topographical situation of its entrance to the respiratory system (respiratory mode), to the thoracoabdominal movement zone that integrates inspiration and expiration. It is supported by the observation with the aid of a Glatzel's mirror to anatomically determine the upper airway status and its functional correlation.

Changes in SpeechBaseline and 8 weeks of treatment.

A clinical evaluation will be carried out by a speech therapist specialized in the area of Orofacial Motricity, to check for possible improvement in speech. For this, the Glatzel test will be used to measure the degree of nasal patency and the functional symmetry of the upper airways both at rest and in function. Specifically in the functional evaluation, its usefulness is linked to the verification of the existence of nasality or hyponasality before vowels elicited by the patient.

Changes in SwallowingBaseline and 8 weeks of treatment.

A clinical evaluation will be carried out by a speech therapist specialized in the area of Orofacial Motricity, to check for possible improvement in swallowing. For this, the Payne's test, which assesses tongue posture both at rest and in function (swallowing), will be used. From instruments such as liquid fluorescein applied to the apex lingual and lateral borders, and Payne's lamp that verifies the vestige of the fluroscein, and therefore the conditions of support, thrust, position and/or obstruction of the tongue.

Changes in the Presence of BruxismBaseline and 8 weeks of treatment.

The bruxism questionnaire will be delivered to parents or guardians, which will be completed prior to treatment and afterwards. The questionnaire contains 4 questions regarding the perceived presence of bruxism, and 5 questions for the dentist to answer, based on a clinical observation. All questions have the options "yes" or "no". The more times the word "yes" is chosen, the greater the risk for bruxism is.

Changes in Sleep QualityBaseline and 8 weeks of treatment.

A Pediatric Sleep Quality Questionnaire will be delivered to parents or guardians, and it will be completed prior to treatment and afterwards. The questionnaire contains 44 questions regarding sleep quality. All questions have the options "yes" or "no". The more times the word "yes" is chosen, the worse is the sleep quality.

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