Traditional Chinese acupuncture for mild to moderate knee osteoarthritis

Not Applicable

Completed

• Conditions: Osteoarthritis; Musculoskeletal Diseases; Mild-moderate knee osteoarthritis

• Registration Number: ISRCTN14016893
• Lead Sponsor: Beijing Municipal Administration of Hospitals

Brief Summary

2016 Protocol article in https://pubmed.ncbi.nlm.nih.gov/27965256/ (added 18/08/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-04
• Study Completion: 2016-12-30
• Last Update Posted: 28 August 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

1. Age between 45 and 75 years
2. Pain in single or double knee joints for at least 6 months
3. Kellgren–Lawrence grade II or III in the last 6 months
4. Morning stiffness at most 30 minutes
5. Signed informed consent

Exclusion Criteria

1. Surgery of the afflicted extremity or waiting for surgery
2. Knee pain induced by other conditions (bone tumor, bone fracture, acute infection, gout, etc)
3. Serious organic or psychiatric diseases (epilepsy, depression, etc.)
4. Severe coagulopathy
5. Pregnant or breast-feeding
6. History of receiving acupuncture, physical therapy, rehabilitation, analgesia, anti-inflammatory medication or cartilage nutrition agent in the past week
7. Current gastrointestinal ulcer
8. Participation in another clinical study in the past three months
9. Inadequacy for this trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response rate is determined using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at baseline and 8 weeks.

Secondary Outcome Measures

Name	Time	Method
1. Pain is measured using WOMAC pain subscore at baseline, 8 weeks, 16 weeks and 26 weeks<br>2. Knee-joint function is measured using WOMAC functional subscore at baseline, 8 weeks, 16 weeks and 26 weeks<br>3. Number of emergency analgesics (Celebrex) used is recorded using Drug Use Form at 8 weeks, 16 weeks and 26 weeks<br>4. Quality of life is measured using the 12-Item Short Form Health Survey (SF-12) at baseline, 8 weeks, 16 weeks and 26 weeks<br>5. Adverse events are measured using Adverse Event Form at 8 weeks and 16 weeks