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临床试验/NCT02344381
NCT02344381已完成不适用

The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.

Northumbria University2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2015年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
15
试验地点
2
主要终点
change in liver glycogen concentration

研究概览

简要总结

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for our ability to perform intense/prolonged endurance exercise. Therefore, it is important to replete these stores after an intense/prolonged endurance exercise session in order to recover and perform optimally during a subsequent exercise bout, especially if the next exercise session is within 24h (e.g. stage races such as the Tour de France, tournament-style competitions such as the Olympic games and ultra-endurance events).

Carbohydrate intake has been shown to increase the availability of glycogen in the muscle and liver after exercise. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. It has been observed that the ingestion of glucose will lead to a maximum rate of absorption of approximately ~1 g/min. However, if we also provide a different source of carbohydrate (fructose) then this is absorbed through a different pathway and therefore we can absorb up to ~1.75 g/min of carbohydrate. In addition, both carbohydrate sources are metabolised differently in the human body. By supplementing both glucose and fructose, we can potentially replenish the liver and muscle glycogen stores at a faster rate than ingestion of glucose only.

Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores post-exercise when supplemented in relatively high amounts. Therefore the aim of this study is to assess whether relative high amounts of sucrose ingestion will improve liver and muscle glycogen repletion after endurance exercise.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Endurance trained cyclists/triathletes
  • VO2 max ≥ 50 ml/kg/min

排除标准

  • Use of medication
  • Metabolic disorders

结局指标

主要结局

change in liver glycogen concentration

时间窗: 5 h

The change in liver glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

次要结局

  • Change in muscle glycogen concentration(5 h)
  • Plasma glucose concentration(5 h)
  • Plasma insulin concentration(5 h)
  • Plasma lactate concentration(5 h)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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