NCT00317954已完成4 期
Spironolactone in Diabetic Nephropathy
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Changes in albuminuria
研究概览
简要总结
The aim of the study was to evaluate the renoprotective effect (i.e. albuminuria- and bloodpressure lowering effect) of spironolactone 25 mg o.d. in type 1 and type 2 diabetic patients with albuminuria despite recommended antihypertensive treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetes Mellitus
- •Diabetic Nephropathy
- •Glomerular filtration rate > 30 ml/min/1.73 m2
- •Blood pressure > 130/80 mm Hg
排除标准
- •Child bearing potential
- •Plasma-potassium >4.5 mmol/l
- •Breastfeeding
- •Abuse of alcohol or drugs
- •Non-diabetic kidney disease
结局指标
主要结局
Changes in albuminuria
Changes in blood pressure
次要结局
- Changes in glomerular filtration rate
研究者
研究点 (2)
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