ZAR2007: R-CHOP in Folicular Lymphoma Patients no Treated Previously. Consolidation With 90Y Ibritumomab Tiuxetan (Zevalin®) Versus Maintenance Treatment With Rituximab (MabThera®)
- Registration Number
- NCT00662948
- Lead Sponsor
- PETHEMA Foundation
- Brief Summary
After conventional induction treatment with R-CHOP (Rituximab, cyclophosphamide, adriamycin, vincristine and prednisone) the patients are randomized to:
A: Consolidation with one dose of 90Y Ibritumomab tiuxetan (Zevalin®) 0,4 mCi/Kg
B: Maintenance with 375 mg/m2 of Rituximab every 8 weeks during 24 months
- Detailed Description
The study will evaluate the benefit of consolidation treatment with 90Y Ibritumomab tiuxetan (Zevalin®) or maintenance with rituximab (MabThera®) in terms of progression free survival, after induction with chemotherapy and rituximab in folicular lymphoma patients no treated previously.
The other aims are, evaluate the global survival, event free survival, time until next treatment, response rate after consolidation or maintenance treatment, quality of life, security of two branches and relation cost-efectivity
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 149
-
Folicular Lymphoma CD20-positive, grade 1, 2 or 3a, confirmed in previous 4 months.
-
Patients no treated previously.
-
Ann Arbor Stage II, III o IV.
-
Symptoms or signes wich indicate necesary treatment (GELF criteria):
- Ganglionar or extraganglionar mass
- B Symptoms
- LDH or B2-microglobuline increased
- 3 ganglionar territory afected (> 3 cm)
- Esplenomegalia
- Compresive syndrome
- Pleural/peritoneal effusion
- Secondary medular insufiency due to infiltration
-
Age> 18 years and <75 years.
-
ECOG < 2
-
Adecuate hematological function: Hemoglobin > 8,0 g/dl (5,0 mmol/L); RAN >1,5 x 109/L; platelets > 100 x 109/L
-
No pregnant women. Women and man should use an appropiate anticonceptive method during the study and one year after
-
Informed consent
- Transformation in high grade lymphoma
- FL grade 3b.
- Skin or gastro-intestinal primary lymphoma
- History of CNS diseases ( or CNS lymphoma)
- Previous treatment
- Regulary treatment with corticosteroids (permited < 20 mg/day prednisone or equivalent).
- Previous cancer diseases
- Major surgery in 28 days before inclusion in study.
- Creatinine > 2,0 mg/dl (197 mmol/L)
- Bilirubin > 2,0 mg/dl (34 mmol/L), AST (SGOT) > 3 x upper normal limit.
- HIV infection or active infection VHB o VHC < 4 weeks before inclusion.
- Other complicated diseases
Criteria investigador:
- Life expectancy < 6 months.
- Hipersensibility to Ibritumomab tiuxetan, rituximab, other murines proteins or any excipients.
- Treatment in other experimental study in previous 30 days
- Any medical o psicologycal condition that can modify the capacity to give the consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description A Ibritumomab tiuxetan Consolidation with one dose of 90Y Ibritumomab tiuxetan (Zevalin®) 0,4 mCi/Kg B Rituximab Maintenance with 375 mg/m2 of Rituximab every 8 weeks during 24 months
- Primary Outcome Measures
Name Time Method Progression free survival 2 years
- Secondary Outcome Measures
Name Time Method Saffetty of two arms 2 years Quality of life 7 years Event free survival 7 years Response rate in two arms 3 years Global survival 7 years
Trial Locations
- Locations (20)
Hospital Dr Pesset
🇪🇸Valencia, Spain
Hospital La Paz
🇪🇸Madrid, Spain
Hospital Doce de Octubre
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
MD Anderson
🇪🇸Madrid, Spain
Hospital Clínic
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Juan Canalejo
🇪🇸La Coruña, Spain
Hospital son Dureta
🇪🇸Palma de Mallorca, Spain
Hospital General
🇪🇸V Alencia, Spain
Hospital de Alcorcón
🇪🇸Alcorcón, Spain
Hospital germans Trias i Pujol
🇪🇸Badalona, Spain
Hospital de la santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Ramón y Cajal
🇪🇸Madrid, Spain
Hoaspital Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital de Donostia
🇪🇸San Sebastián, Spain
Hospital Virgen de la Arrixaca
🇪🇸Murcia, Spain
Hospital Clínico
🇪🇸Valencia, Spain
Hospital Clínico Universitario
🇪🇸Santiago de Compostela, Spain
Hospital La Fe
🇪🇸Valencia, Spain