Incidence of Residual Neuromuscular Blockade in the Postanaesthesia Care Unit: An Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 288
- 试验地点
- 1
- 主要终点
- Patients having neuromuscular blockade TOF ratio less than 0.9.
研究概览
简要总结
Residual neuromuscular blockade is a known cause of postoperative complications
after general anaesthesia with relaxants. Various reasons have been cited for this, including
but not limited to the type of surgery, duration of surgery, neuromuscular blocker used, dose
of Neuromuscular blockade and the type and dose of reversal used. Many measures have
been suggested to reduce the incidence of Residual neuromuscular blockade, like adequate
titration of dose of Neuromuscular blockade and reversal used and timing of the reversal
agent, to preclude Residual neuromuscular blockade but various studies continue to show
significant incidence of Residual Neuromuscular blockade and its associated morbidity.
Neuromuscular monitoring is a useful tool, both intraoperatively and postoperatively to guide
Neuromuscular blockade use and reversal but is not used often and to its potential. It can
significantly reduce the incidences of Residual neuromuscular blockade.
We aim to conduct an observational study into the incidence of Residual
neuromuscular blockade in the post anaesthesia care unit of patients undergoing surgery in
general anaesthesia with muscle relaxants. This study will include 290 Patients. All patients
found eligible and who consent to the study will be enrolled. Demographic and clinical
details of the patients will be noted. All patients undergoing surgery under general
anaesthesia, will be checked for Residual neuromuscular blockade with a neuromuscular
monitor using Train of four mode, on their arrival to the Post anaesthesia care unit. Patients
having a TOF ratio < 0.9 will be considered to have a Residual neuromuscular blockade.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)(—)
- 性别
- All
入选标准
- •ASA physical classification I to II
- •Patients undergoing lower abdominal surgery, general, urological, or gynaecologic surgery under general anaesthesia with neuromuscular blockade.
排除标准
- •Patients not consenting.
- •Patients with known neuromuscular disorders (e.g. myasthenia gravis)
- •Patients undergoing organ transplant surgery, open upper abdominal surgery, emergency procedures, and patients needing intensive care admission in the post-operative period.
- •Patient undergoing thoracic surgery.
结局指标
主要结局
Patients having neuromuscular blockade TOF ratio less than 0.9.
时间窗: 10 mins after extubation
次要结局
- a. Fall of SpO2 less than 95 % on oxygen support.(b. Duration of stay in PACU.)
研究者
Dr Savitar Malhotra
Institute of Anaesthesiology Pain and Perioperative Medicine
