The Effect of Different Contouring Techniques on Cardiac Magnetic Resonance Assessment of Right Ventricular Volumes in Repaired Tetraology of Fallot: Implications on Preoperative Thresholds for Intervention
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Tetralogy of Fallot
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- Difference in the baseline measurement of indexed right ventricular end-diastolic volume according to the contouring technique
- Last Updated
- 6 years ago
Overview
Brief Summary
Patients with repaired tetralogy of Fallot (RTOF) develop chronic pulmonary regurgitation and require monitoring for right ventricular dilatation. Pulmonary valve replacement can prevent irreversible right ventricular (RV) dilatation and dysfunction and cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. The investigators sought to determine whether the choice of myocardial contouring technique affects preoperative RV volumetric thresholds for intervention.
Detailed Description
Participants with repaired tetralogy of Fallot (RTOF) will be identified using existing patient electronic records who have developed chronic pulmonary regurgitation and are undergoing monitoring for right ventricular dilatation. Cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. Pulmonary valve replacement can prevent irreversible right ventricular (RV) dilatation and dysfunction and cardiac magnetic resonance (CMR) is used to facilitate its optimal timing. There are different post-processing techniques published for measuring RV volumes on cardiac magnetic resonance imaging (detailed vs. smoothed and manual vs. automated). The primary aim of this study is to identify whether the choice of myocardial contouring technique affects the preoperative RV volumetric thresholds for intervention. As a secondary aim, the investigators will determine the reproducibility of different contouring methods.
Investigators
William E Moody
Consultant Cardiologist
University Hospital Birmingham NHS Foundation Trust
Eligibility Criteria
Inclusion Criteria
- •Consecutive patients with repaired Tetralogy of Fallot undergoing routine clinical surveillance at a Level 1 ACHD surgical referral centre.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Difference in the baseline measurement of indexed right ventricular end-diastolic volume according to the contouring technique
Time Frame: Cross-sectional study. Repeated measurements performed on the baseline CMR study.
Measurements of indexed right ventricular end-diastolic volume will be repeated using different contouring techniques on the same cardiac MRI study performed at baseline pre-surgery.