Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma Patients

Phase 1

• Conditions: Hyperprolactinoma

• Registration Number: NCT01344291
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Prolactinoma is the most prevalent anterior hypophysis tumor. The principal treatment for this disorder is Dopamine agonist drugs including bromocriptin and Cabergoline. However, 50% of Bromocriptin treated and 17% of Cabergoline treated patients are resistant to these drugs. Curcumin is the main derivative of turmeric ,an old spice which is used frequently in Indian and Iranian cuisine. It has been proved that curcumin can reduce mammotrope cells proliferation and also intracellular hormone production. The purpose of this study is to evaluate the effect of turmeric on prolactinoma patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-04-18
• Study First Submitted QC: 2011-04-27
• Study First Posted: 2011-04-29
• Study Start: 2011-07
• Status Verified: 2011-10
• Last Update Submitted: 2011-10-29
• Last Update Posted: 2011-11-01
• Primary Completion: 2012-07
• Study Completion: 2012-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

• hyperprolactinemia
• microprolactinoma

Exclusion Criteria

• pregnancy
• macroadenoma
• neurologic signs due to tumor

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
serum prolactin level	2weeks and one month after treatment

Secondary Outcome Measures

Name	Time	Method
change in LH,FSH and estradiol from baseline	one month ofter treatment

Trial Locations

Locations (1)

Mashad University of Medical Sciences; 🇮🇷 Mashad, Khorasan Razavi, Iran, Islamic Republic of