Testing a lower than standard dose of phenylephrine and cyclopentolate in neonates requiring pupil dilation for routine retinopathy of prematurity screening and red reflex testing.

All infants had a successful retinopathy of prematurity eye examination following the administration of both eye drop regimens. Preliminary data analysis suggests that low dose and very low dose microdrop administration of cyclopentolate and phenylephrine is effective at dilating the neonatal pupil for retinopathy of prematurity eye examinations. Preliminary analysis of the safety data suggests no clinically or statistically significant difference in cardiovascular, respiratory or gastrointestinal effects.