Glymphatic system clearance of a radiotracer in patients with craniectomy and dementia: A prospective pilot study - NI

Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER)0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年10月16日

试验速览

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•Decompressive craniectomy group
•Adult (18 years or older) traumatic brain injury (TBI) patients who have undergone a decompressive craniectomy at least three months back.
•Decompressive craniectomy has to have the largest dimension of 12 cm or more on CT scan
•The brain under the craniectomy defect should not have gross damage, volume loss, or infarcts though some porencephalic changes due to previous head trauma are expected.
•Adults with Probable dementia
•Objective cognitive or behavioral impairment in at least two of the following Memory, Reasoning and handling complex tasks Visuospatial abilities, Language functions, Personality, behavior, or comportment
•A decline from the previous level of functioning Functional impairment
•Insidious onset and gradual progression
•Initial symptoms
•Nonamnestic (language, executive)
•No other neurologic, psychiatric, or general medical disorders of severity that can interfere with cognition

•Exclusion criteria for both groups:
•Abnormal creatinine levels for the age group. The creatinine clearance should be normal as the urinary excretion data will be affected if the kidney function is abnormal.

发起方

Jawaharlal Institute of Post-graduate Medical Education and Research (JIPMER)