A clinical trial looking at the efficacy and optimal dose of acetic acid in burn wound infections

Phase 2

Completed

• Conditions: Burn wound infections; Infections and Infestations

• Registration Number: ISRCTN11636684
• Lead Sponsor: niversity Hospitals Birmingham NHS Foundation Trust

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37748846/ (added 26/09/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-01-29
• Study Completion: 2022-01-04
• Last Update Posted: 9 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Current inclusion criteria as of 27/11/2020:
1. At least one =1% TBSA burn injury prior to enrolment
2. Burn wound colonised with a specifically identifiable bacterium
3. Aged =16 years old
4. Anticipated to remain as inpatient for the study duration i.e. 3 days

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Previous inclusion criteria as of 03/08/2018:
1. Patient to have a =1% TBSA burn injury/ies prior to enrolment
2. Burn wound colonised with a specifically identifiable bacteria
3. Patients aged =18 years old
4. Patients who are anticipated to remain as inpatients for the study duration i.e. 5 days

_____

Previous inclusion criteria:
1. Patient to have a 1 - <10 % TBSA burn injury prior to enrolment
2. Burn wound colonised with a specifically identifiable bacteria
3. Patients aged =18 years old
4. Patients who are anticipated to remain as inpatients for the study duration i.e. 5 day

Exclusion Criteria

Current inclusion criteria as of 27/11/2020:
1. Burns solely to the face and/or genital area
2. Patients who have received acetic acid as part of standard therapy upon admission to inpatients for this burn injury
3. Patients deemed unsuitable to enter trial in the opinion of the investigator

_____

Previous exclusion criteria as of 03/08/2018:
1. Patients who lack capacity to give informed consent (NB: translation services will be available for non-English speaking patients)
2. Patients who are on antibiotics for cellulitis
3. Patients with burns solely to the face and/or genital area
4. Patients who have received acetic acid as part of standard therapy upon admission to inpatients for this burn injury
5. Patients deemed unsuitable to enter trial in the opinion of the investigator

_____

Previous exclusion criteria:
1. Patients who lack capacity to give informed consent (NB: translation services will be available for non-English speaking patients)
2. Patients who are receiving systemic antibiotics
3. Patients with burns solely to the face and/or genital area
4. Patients who have received acetic acid as part of standard therapy upon admission to inpatients for this burn injury
5. Patients deemed unsuitable to enter trial in the opinion of the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified