Sevoflurane's Effect on Tissue Doppler Profiles of Lateral Mitral Annulus During Cardiac Surgery
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Peak mitral annular velocity during early filling (E')
研究概览
简要总结
The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE)in cardiac surgery patients.
详细描述
Following data would be determined after 10 min-exposure to each dosage of sevoflurane with 1.0, 2.0 and 3.0 inspired vol% (T1, T2 and T3, respectively) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=14):
- TDI of lateral mitral annulus at systole (S'), early filling (E') and atrial contraction (A')
- transmitral flow Doppler at early filling (E), atrial contraction (A), deceleration time;
- LV-ejection fraction (EF)
- bispectral index (BIS)
- phenylephrine-infusion rate
- other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), mixed venous O2 saturation (SvO2), cardiac index (CI) and stroke volume index (SVI)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing cardiac surgery
排除标准
- •low ejection fraction < 50% in preoperative transthoracic echocardiography
- •atrial fibrillation
- •pacemaker
- •pericardial and infiltrative myocardial disease
- •mitral annular calcification, surgical rings, prosthetic mitral valves
- •lateral left ventricular regional wall motion abnormality
- •esophageal spasm,stricture, laceration, perforation, and diverticulum
- •diaphragmatic hernia,
- •history of extensive radiation to the mediastinum
- •upper gastrointestinal bleeding
研究组 & 干预措施
sevoflurane
10 min exposure to sevoflurane 1.0, 2.0 and 3.0 inspiratory vol% at sevoflurane dosage titration
干预措施: Sevoflurane dosage titration (Drug)
结局指标
主要结局
Peak mitral annular velocity during early filling (E')
时间窗: after 10 min exposure to sevoflurane of 1.0 vol%, 2.0 vol% and 3.0 vol%
By using pulsed Doppler with the sample volume positioned at the lateral MV ring in the midesophageal 4-chamber view, E' would be determined just after the 10 min-exposure to each concentration of sevoflurane, 1.0 inspired vol%, 2.0 inspired vol% and 3.0 inspired vol% (T1, T2 and T3, respectively)
peak mitral annular velocity during atrial contraction(A')
时间窗: after 10 min exposure to sevoflurane 1.0 vol%, 2.0 vol% and 3.0 vol%
By using pulsed Doppler with the sample volume positioned at the lateral MV ring in the midesophageal 4-chamber view, A' would be determined just after the 10 min-exposure to each concentration of sevoflurane, 1.0 inspired vol%, 2.0 inspired vol% and 3.0 inspired vol% (T1, T2 and T3, respectively)
Peak mitral annular velocity during systole (S')
时间窗: after 10 min exposure to sevoflurane 1.0 vol%, 2.0 vol% and 3.0 vol%
By using pulsed Doppler with the sample volume positioned at the lateral MV ring in the midesophageal 4-chamber view, S' would be determined just after the 10 min-exposure to each concentration of sevoflurane, 1.0 inspired vol%, 2.0 inspired vol% and 3.0 inspired vol% (T1, T2 and T3, respectively)
次要结局
- ejection fraction (EF)(after 10 min exposure to sevoflrane 1.0vol%, 2.0 vol% and 3.0 vol%)
- peak velocity of mitral inflow during atrial contraction (A)(after 10 min exposure to sevoflurane 1.0 vol%, 2.0 vol% and 3.0 vol%)
- peak velocity of mitral inflow during early relaxation (E)(after 10 min exposure to sevoflurane 1.0 vol%, 2.0 vol% and 3.0 vol%)
- bispectral index (BIS)(after 10 min exposure to sevoflurane 1.0 vol%, 2.0 vol% and 3.0 vol%)
研究者
Tae-Yop Kim, MD PhD
Professor of Anesthesiology
Konkuk University Medical Center