The Effect of High Intensity Interval Training on Cardiovascular Fitness in People With Progressive Multiple Sclerosis.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- heart rate max
研究概览
简要总结
This is a pilot trial to explore the cardiovascular of eight weeks of twice weekly high intensity interval training in people with progressive multiple sclerosis. A control group of people with progressive multiple sclerosis will undergo continuous moderate intensity exercise, twice weekly for 8 weeks.
详细描述
This is a pilot trial to explore the cardiovascular of eight weeks of twice weekly high intensity interval training in people with progressive multiple sclerosis. A control group of people with progressive multiple sclerosis will undergo continuous moderate intensity exercise, twice weekly for 8 weeks.
The training program will entail 6x1.5 minute intervals working at 80-95% heart rate max on a cycle ergometer. Each interval will be interspersed with 1.5 minutes of working rest at a light resistance of the participant's choosing.
The continuous moderate intensity exercise program will entail 20 minutes on a cycle ergometer working at 60-70% heart rate max.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed with a progressive form of MS
- •Aged 18 years or older
- •Known to members of staff of the MS service NHS Ayrshire & Arran
- •Ability to attend Douglas Grant Rehabilitation centre twice a week for eight weeks
- •EDSS 4-6.0
- •Able to cycle on ergometer
排除标准
- •A relapse of symptoms requiring treatment within the past three months.
- •A respiratory condition that would be exacerbated by high intensity exercise including but not limited to: chronic obstructive pulmonary disorder, uncontrolled or poorly controlled asthma.
- •Uncontrolled high pressure at screening (>190/100 mmHg)
- •Cognitive impairment affecting ability to understand instructions as noted in patient's notes.
- •Currently engaging in another research trial for their MS or that may affect their physiological or cardiovascular outcomes
- •Weighing more than 110 kg (weight limit of ergometer)
- •Any pathology or medical intervention that would preclude high intensity exercise, maximal exertion testing or could attenuate the cardiovascular effect of exercise including but not limited to: unstable angina; diabetes; peripheral vascular disease or intermittent claudication; having a pace maker or medicine pump; surgical clips; having another neurological condition other than MS; and pregnancy. To be established from patient's notes and at screening session.
- •A serious cardiovascular event in the past year including but not limited to: transient ischaemic attack, cerebrovascular event and myocardial infarction.
- •Taking any of the following medication: beta blockers; vasodilators; ACE inhibitors; diuretics or any other medication that could cause exercise induced hypotension; hypoglycaemic insulin; metformin or other oral insulin medicine.
研究组 & 干预措施
Intervention
8 weeks of twice weekly high intensity interval training. Session protocol: 2 minute warm up at nominal resistance on cycle ergometer, 6 six intervals of 80-95% heart rate max interspersed with 6 intervals of 1.5 minute working rest. Then 3 minutes cool down.
干预措施: High intensity interval training (Other)
control
8 weeks of twice weekly continuous moderate intensity exercise. Session protocol: 2 minutes warm up at nominal resistance on cycle ergometer, 20 minutes at 60-70% heart rate max. Then 3 minutes cool down.
干预措施: Continuous moderate exercise (Other)
结局指标
主要结局
heart rate max
时间窗: 8 weeks
Maximal heart rate elicited during a maximal exertion test
次要结局
- Resting heart rate(8 weeks)
- Brain derived neurotrophic factor(8 weeks)
- Fatigue severity scale(8 weeks)
- Resting blood pressure(8 weeks)
- Lactate(8 weeks)
- Timed 25 foot walk test(8 weeks)
- Symbol digit modalities test(8 weeks)
- Lipoprotein profile(8 weeks)
- MSIS-29 version 2(8 weeks)
- Hospital anxiety and depression scale(8 weeks)
研究者
Evan Campbell
PhD Student
University of Glasgow