NCT05743192已完成不适用
Discontinuation of Antibiotic Susceptibility Testing on Monobacterial Enterococcus Faecalis Positive Urine Cultures: an Impact on Antibiotic Prescriptions?
Central Hospital, Nancy, France1 个研究点 分布在 1 个国家目标入组 217 人开始时间: 2023年2月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 217
- 试验地点
- 1
- 主要终点
- Proportion of positive urine culture for which antibiotic therapy was prescribed (%)
研究概览
简要总结
The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients. The secondary objectives are to evaluate the impact of this intervention on antibiotic prescription rates as well as on antibiotic consumption according to: patient gender, type of antibiotic therapy (probabilistic/documented) and diagnosis (urinary tract infection or colonization). It is hypothesized that antibiotic consumption is lower after the application of the absence of antibiotic susceptibility reporting compared to before.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Person having received complete information on the organization of the research and not having objected to the exploitation of these data
- •Adult patients (More than 18);
- •Having performed a urine culture at the Nancy University Hospital, taken from the 2nd urine stream, by urinary catheter or via a suprapubic catheter and whose culture is positive for monomicrobial E. faecalis with a bacteriuria threshold greater than or equal to 10^3 CFU/field;
- •Hospitalized at the Nancy University Hospital at least 72 hours after validation of the antibiotic susceptibility test in the pre-intervention period and at least 72 hours after validation of the culture in the post-intervention period.
排除标准
- •Inpatients in hematology, critical care/intensive care, consultation and day hospital units;
- •Urine cultures performed in ambulatory units ;
- •Urine culture performed in the critical care/intensive care/hematology units;
- •Patients discharged from hospital/deceased/transferred to intensive care within 72 hours of the validation of the antibiotic susceptibility test or the validation of the urine culture;
- •Patients with associated E. faecalis bacteremia;
- •Urine culture without an antibiotic susceptibility test for the pre-intervention period;
- •Urine culture with a monomicrobial history of less than 1 week;
- •Culture of urine from pyelic punctures or nephrostomy tubes - conservation of those from second streams, urinary catheters and suprapubic catheters).
结局指标
主要结局
Proportion of positive urine culture for which antibiotic therapy was prescribed (%)
时间窗: Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist
次要结局
- Prescription rate of each antibiotic class/molecule (%)(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Prescription rate of each antibiotic class/molecule (%) by patient gender(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Proportion of urine cultures for which antibiotic therapy was prescribed (%) by diagnosis(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Prescription rate of each antibiotic class/molecule (%) by type of antibiotic therapy.(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Proportion of urine cultures for which antibiotic therapy was prescribed (%) by sex of patient(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Proportion of urine cultures for which antibiotic therapy was prescribed (%) by type of antibiotic therapy.(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
- Prescription rate of each antibiotic class/molecule (%) by diagnosis(Between 24 hours before the urine culture is collected and 72 hours following the validation of the antibiotic susceptibility test/the urine culture by the biologist)
研究者
BARONNET Guillaume
MD, Infectious diseases department
Central Hospital, Nancy, France
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Point of Care Susceptibility Testing in Primary CareUrinary Tract InfectionsNCT02323087University of Copenhagen377
Unknown
4 期
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the First-line Helicobacter Pylori Eradication.Antimicrobial Susceptibility TestingHelicobacter Pylori InfectionNCT03571230Shandong University400
Unknown
4 期
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori InfectionHelicobacter Pylori InfectionNCT03565484Shandong University400
已完成
4 期
Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori InfectionHelicobacter Pylori InfectionNCT03658746Shandong University420
进行中（未招募）
Unknown
Development of a point-of-care antibiotic susceptibility test for urinary tract infectionsISRCTN23042419niversity of Reading500