IRON DEFICIENCY ANEMIA IN RELATION TO PINCH STRENGTH AND HAND DEXTERITY IN PRESCHOOL CHILDREN
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- manual dexterity
研究概览
简要总结
Anemia is a major public health problem among preschool-aged children. The evidence demonstrated that early childhood anemia is a strong predictor of adulthood anemia (Gessner, 2009). According to Egypt's Demographic and Health Survey (EDHS), prevalence rates of anemia in children aged 6-59 months ranged from 23% to 45% (EDHS, 2014). It is assumed that 50% of the cases of anemia are due to ID (Aref and Khalifa, 2019). The major health problem in Egypt is ID that affects 41.2% of children aged <5years (El-Asheer et al., 2021). The total prevalence of IDA in the Nile Delta region was 17.19% of the children (El-Shanshory et al., 2021). Iron is a trace element that is essential to form hemoglobin in red blood cells and to carry oxygen to peripheral tissues. In addition, iron plays essential functions in the mitochondria, which are crucial for regulating energy metabolism in the skeletal muscle (Kang and Li, 2012). And low iron levels limit oxygen bioavailability in the peripheral tissues, including skeletal muscle (Jolly et al., 2001).Yu-mi et al., (2020) found a low handgrip strength in anemic patients. Also, ID can impaired brain energy metabolism, along with hypo-myelination and impaired dopamine signaling, is consistently described as one of the mechanistic causes of the neurodevelopmental deficits associated with early-life ID (Thomas et al., 2020).
HYPOTHESES:
There is a relation between IDA and pinch strength and hand dexterity in preschool children.
RESEARCH QUESTION:
Is there a relation between IDA and pinch strength and hand dexterity in preschool children?
The purpose of the current study is to find the relation between IDA and:
- Pinch grip strength (tripod and tip to tip grip strength).
- Hand dexterity in preschool children.
详细描述
i. Instrumentations for selection:
- Fully automated blood cell counter. A complete blood count (CBC) is one of the most commonly and routinely done laboratory tests It will be obtained through the use of fully automated blood cell counter (sysmex-Xs 800i).
- Beckman coulter-AU 480- blood chemistry auto-analyzer. It is the ideal primary chemistry analyzer for measurement of the amount of serum iron in the blood. ii. Instrumentations for assessment:
Updated 23/11/12
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- Baseline mechanical Pinch gauge (0-60 lb.) used to measure tripod pinch strength of dominance and non-dominance hands for all participated children.
- Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2) The Bruininks-Oseretsky Test of Motor Proficiency is a standardized, norm-referenced measure
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Years 至 6 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Children will exclude if they have:
- •Congenital or acquired deformity in the joints of upper limb.
- •Unhealed fracture in upper limb bones.
- •Systematic disease that cause anemia such as renal or hepatic failure or a history of bone disease.
- •Blood transfusion within 3 months before measuring the hematological indices.
- •Documented trauma in the previous 12 months in the muscle fibers, or those taking medication that affecting strength.
- •Children begin with musculoskeletal problems or neurological disorders that affected their upper extremities
- •Children who practice in any regular sport activities involving the upper extremities.8)
结局指标
主要结局
manual dexterity
时间窗: one year
Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2)
hemoglobin and serum iron levels
时间窗: one year
Fully automated blood cell counter (sysmex-Xs 800i) and AU 480-Chemistry auto-analyzer
measure tip to tip and tripod pinch strength
时间窗: one year
Baseline mechanical Pinch gauge (0-60 lb.) used to measure tip to tip and tripod pinch strength for all participated children
次要结局
未报告次要终点
研究者
Fatma Essam ELDIN ABDALLAH AMER
Physical therapist at Zagazig General Hospital, El Sharkia, Egypt.
Cairo University
