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临床试验/NCT05959122
NCT05959122已完成不适用

IRON DEFICIENCY ANEMIA IN RELATION TO PINCH STRENGTH AND HAND DEXTERITY IN PRESCHOOL CHILDREN

Cairo University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2022年5月20日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
100
试验地点
1
主要终点
manual dexterity

研究概览

简要总结

Anemia is a major public health problem among preschool-aged children. The evidence demonstrated that early childhood anemia is a strong predictor of adulthood anemia (Gessner, 2009). According to Egypt's Demographic and Health Survey (EDHS), prevalence rates of anemia in children aged 6-59 months ranged from 23% to 45% (EDHS, 2014). It is assumed that 50% of the cases of anemia are due to ID (Aref and Khalifa, 2019). The major health problem in Egypt is ID that affects 41.2% of children aged <5years (El-Asheer et al., 2021). The total prevalence of IDA in the Nile Delta region was 17.19% of the children (El-Shanshory et al., 2021). Iron is a trace element that is essential to form hemoglobin in red blood cells and to carry oxygen to peripheral tissues. In addition, iron plays essential functions in the mitochondria, which are crucial for regulating energy metabolism in the skeletal muscle (Kang and Li, 2012). And low iron levels limit oxygen bioavailability in the peripheral tissues, including skeletal muscle (Jolly et al., 2001).Yu-mi et al., (2020) found a low handgrip strength in anemic patients. Also, ID can impaired brain energy metabolism, along with hypo-myelination and impaired dopamine signaling, is consistently described as one of the mechanistic causes of the neurodevelopmental deficits associated with early-life ID (Thomas et al., 2020).

HYPOTHESES:

There is a relation between IDA and pinch strength and hand dexterity in preschool children.

RESEARCH QUESTION:

Is there a relation between IDA and pinch strength and hand dexterity in preschool children?

The purpose of the current study is to find the relation between IDA and:

  1. Pinch grip strength (tripod and tip to tip grip strength).
  2. Hand dexterity in preschool children.

详细描述

i. Instrumentations for selection:

  1. Fully automated blood cell counter. A complete blood count (CBC) is one of the most commonly and routinely done laboratory tests It will be obtained through the use of fully automated blood cell counter (sysmex-Xs 800i).
  2. Beckman coulter-AU 480- blood chemistry auto-analyzer. It is the ideal primary chemistry analyzer for measurement of the amount of serum iron in the blood. ii. Instrumentations for assessment:

Updated 23/11/12

4

  1. Baseline mechanical Pinch gauge (0-60 lb.) used to measure tripod pinch strength of dominance and non-dominance hands for all participated children.
  2. Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2) The Bruininks-Oseretsky Test of Motor Proficiency is a standardized, norm-referenced measure

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Cross Sectional

入排标准

年龄范围
5 Years 至 6 Years(Child)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • Children will exclude if they have:
  • Congenital or acquired deformity in the joints of upper limb.
  • Unhealed fracture in upper limb bones.
  • Systematic disease that cause anemia such as renal or hepatic failure or a history of bone disease.
  • Blood transfusion within 3 months before measuring the hematological indices.
  • Documented trauma in the previous 12 months in the muscle fibers, or those taking medication that affecting strength.
  • Children begin with musculoskeletal problems or neurological disorders that affected their upper extremities
  • Children who practice in any regular sport activities involving the upper extremities.8)

结局指标

主要结局

manual dexterity

时间窗: one year

Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2)

hemoglobin and serum iron levels

时间窗: one year

Fully automated blood cell counter (sysmex-Xs 800i) and AU 480-Chemistry auto-analyzer

measure tip to tip and tripod pinch strength

时间窗: one year

Baseline mechanical Pinch gauge (0-60 lb.) used to measure tip to tip and tripod pinch strength for all participated children

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Fatma Essam ELDIN ABDALLAH AMER

Physical therapist at Zagazig General Hospital, El Sharkia, Egypt.

Cairo University

研究点 (1)

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