Characterization of the Homeostatic Functions of Eosinophils in Asthma: An Exploratory Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Flow cytometry based eosinophil phenotyping : Expression levels of cell markers CD62L, CD123, CD101, CD11b, CD193, CD125, Siglec-8 on blood eosinophils quantified by flow cytometry and expressed in % and MFI (mean fluorescence intensity)
研究概览
简要总结
The HOMEOS study is an exploratory, observational, and monocentric research. It focuses on characterizing the homeostatic roles of eosinophils in severe asthma. The primary objective is to identify eosinophil subpopulations among different groups of severe asthmatic patients using flow cytometry. The study aims to advance understanding of eosinophil diversity, which could guide new therapeutic approaches .
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with mild asthma with severe asthma (Biologic-naïve, responders to anti-eosinophil biologic therapies and resistant to anti-eosinophil biologic therapies), control subjects without asthma
- •Signature of informed consent
- •Affiliation with the French social security system
排除标准
- •Non-eosinophilic asthma
- •Coexistence of a chronic eosinophilic inflammatory condition other than asthma
- •Other respiratory conditions (cystic fibrosis, COPD, allergic bronchopulmonary aspergillosis, etc.)
- •Treatment with corticosteroids within 10 days prior to inclusion
- •Active smoking or a smoking history of more than 20 pack-years
- •Pregnant women
- •Legal incapacity or limited legal capacity
- •Subject unlikely to cooperate with the study and/or with anticipated low cooperation as assessed by the investigator
- •Subject without health insurance
- •Subject currently in an exclusion period of another study or as indicated by the "national registry of volunteers."
研究组 & 干预措施
Severe Asthma Patients : Biologic Naïves
Severe Asthma Patients : Biologic Naïves
干预措施: Blood Punction (Procedure)
Severe Asthma Patients: Responders to Biologics
Severe Asthma Patients: Responders to Biologics
干预措施: Blood Punction (Procedure)
Severe Asthma Patients: Non Responders to Biologics
Severe Asthma Patients: Non Responders to Biologics
干预措施: Blood Punction (Procedure)
Mild asthmatics
Mild asthmatics
干预措施: Blood Punction (Procedure)
Healthy Controls
Healthy Controls
干预措施: Blood Punction (Procedure)
结局指标
主要结局
Flow cytometry based eosinophil phenotyping : Expression levels of cell markers CD62L, CD123, CD101, CD11b, CD193, CD125, Siglec-8 on blood eosinophils quantified by flow cytometry and expressed in % and MFI (mean fluorescence intensity)
时间窗: at inclusion
Expression levels of cell markers CD62L, CD123, CD101, CD11b, CD193, CD125, Siglec-8 on blood eosinophils quantified by flow cytometry and expressed in % and MFI (mean fluorescence intensity)
次要结局
未报告次要终点