Suppress the joint destruction in clinical remission patients who have active synovitis of ultrasonographic assessment by increasing the dose of methotrexate
Not Applicable
- Conditions
- rheumatoid arthritis
- Registration Number
- JPRN-UMIN000009535
- Lead Sponsor
- Osaka City University Medical School
- Brief Summary
Clinical remission according to composite indexes allowed the presence of subclinical active synovitis that might induce structural joint damages. Subclinical active synovitis should be controlled by additional treatment and this results in the prevention of the joint damage progression. Evaluation of subclinical active synovitis by using high resolution US should be important even in patients achieving clinical remission and it should be treated more intensively if active synovitis is positive.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 134
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who can not use oral MTX due to side effects. Patients with other diseases that can affect the infllamation state. Patients who was deemed inappropriate by test doctor to participate in this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method