Evaluation of Cefixime and Ofloxacin as an adjunct to scaling and root planing in the treatment of generalized chronic periodontitis - A clinicomicrobiological study
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Reduction of clinical signs of periodontitis, reduction in bleeding on probing, clinical attachment level and periodontal pocket depth.
研究概览
简要总结
The Cefixime-Ofloxacin combination has no drug-drug interaction and is non-toxic as predicted through computational analysis. The administration of both these drugs in combination could be highly safe without cross reactions. This combination of Cefixime and Ofloxacin improves the efficiency of treatment by acting and inhibiting two different targets, with a short course of therapy. Cefixime-Ofloxacin combination showed synergy in the time kill assay and highest bactericidal activity at 24 hours compared to Cefixime or Ofloxacin alone.
There are few studies regarding combination of Cefixime and Ofloxacin in treatment of periodontal diseases. Henceforth, the present study aims to evaluate the clinical and microbiological effect of Cefixime-Ofloxacin combination as an adjunct to scaling and root planing treatment in chronic periodontitis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.willingness to comply with the study protocol.
- •2.Systemically healthy individuals who are diagnosed with chronic periodontitis.
- •3.Subjects who are having more than 20 teeth.
排除标准
- •1.Subjects who has undergone antibiotic therapy within 6 months prior the study.
- •2.Subjects who has allergy to any medications.
- •3.Pregnant and lactating females.
- •4.Subjects who were suffering from any systemic diseases and smokers.
- •Unable or not willing to comply with the study protocol.
- •Subjects who take any antibacterial drug within the study period.
结局指标
主要结局
Reduction of clinical signs of periodontitis, reduction in bleeding on probing, clinical attachment level and periodontal pocket depth.
时间窗: 0 and 90th day
次要结局
- Reduction of clinical signs of periodontitis, reduction in bleeding on probing, clinical attachment level and periodontal pocket depth.(0 and 90th day)