The effects of saffron supplementation on oxidative stress biomarkers, inflammatory factors, and clinical outcomes in sepsis patients admitted to the intensive care unit (ICU): A double-blind randomized controlled clinical trial

Esfahan University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年5月27日

试验速览

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•Age between 18 and 80 years
•Consent of the patient or his legal guardian
•Digestive system with normal function and intestinal nutrition criteria
•Diagnosis of sepsis based on sepsis-3 criteria and confirmation anesthesiologist or infectious disease specialist.

•Patient or his legal guardian dissatisfaction
•Patients who are hospitalized in the ICU for less than 48 hours or who cannot be fed enterally
•Patients who do not have an indication for enteral nutrition on the first day, and based on the diagnosis of the special care department, it is confirmed and predicted that they will not be able to receive enteral nutrition in the future.
•Patients who have cancer and are undergoing chemotherapy and taking cisplatin.
•Patients with congenital and immune disorders, kidney and liver failure, and pancreatitis.
•Patients taking anticonvulsants phenobarbital, Levetiracetam and phenytoin.
•Patients undergoing dialysis.
•Pregnancy and breastfeeding
•Septic shock or severe sepsis
•Patients expected to die within 2 days of admission to the ICU.
•Patients with BMI<18.5 kg/m2
•Patients using other herbal supplements
•Allergy to herbal supplements or spices
•Patients with GCS levels less than 3 or more than 13

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