NCT03181230已完成不适用
Pilot Study of Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Peak oxygen consumption
研究概览
简要总结
This study plans to learn more about how the energy system works in girls with Turner syndrome. This is important to know so that the investigators understand how Turner syndrome relates to diseases such as diabetes, extra weight gain, heart disease and liver disease, and how this impacts day to day life.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 12 Years 至 21 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 12-21 years
- •45,XO karyotype in >50% of cells tested with a diagnosis of Turner syndrome (TS)
- •Tanner stage 2-5 for breast development
排除标准
- •Growth hormone treatment within the past 3 months
- •Diagnosis of type 1 or type 2 diabetes
- •Untreated hypertension with blood pressure > 99%ile for sex, age and height or >140/90
- •Weight > 300 lbs
- •Height < 54"
- •Aortic sinus of Valsalva or ascending aorta z-score > 2
- •Other cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures, including vigorous exercise
- •Pregnancy
结局指标
主要结局
Peak oxygen consumption
时间窗: Baseline
Peak oxygen consumption (VO2 peak) with a standard graded exercise (bicycle) test
次要结局
- Quality of Life Survey(Baseline)
- Percent body fat(Baseline)
- Insulin resistance (IR)(Baseline)
研究者
研究点 (1)
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