Risk stratification and advancing precision therapy strategies for Oral Squamous Cell Carcinoma (OSCC) through the integration of Nanotechnology-enhanced Nutritional interventions with comprehensive Randomized controlled Trials: Exploring the Therapeutic potential of targeting Iron-Responsive Elements (IREs) and their binding proteins.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month
研究概览
简要总结
Oral Squamous Cell Carcinoma (OSCC) remains a significant global health challenge due to its aggressive nature and poor prognosis in advanced stages. Traditional therapeutic approaches often fall short in effectively addressing the heterogeneity and complexity of OSCC. To improve outcomes, there is a pressing need for strategies that offer precise risk stratification and tailored therapeutic interventions.
The trial seeks to advance precision therapy for OSCC by integrating cutting-edge nanotechnology-enhanced nutritional interventions within the framework of comprehensive randomised controlled trials (RCTs). Specifically, the trial will explore the therapeutic potential of targeting Iron-Responsive Elements (IREs) and their binding proteins, which play a critical role in cellular iron metabolism and have been implicated in cancer progression. By focusing on these molecular targets, the trial aims to develop more effective, personalized treatment strategies that could lead to better management and prognosis of OSCC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •Non habit OSCC patients and healthy individuals.
排除标准
- •patient without habits.
结局指标
主要结局
Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month
时间窗: Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month
次要结局
- Response Rate (RR), Quality of Life (QoL),Biomarker Response,(Safety and Tolerability)
研究者
Hema Shree K
Saveetha Dental College, SIMATS
