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临床试验/CTRI/2024/10/075945
CTRI/2024/10/075945尚未招募不适用

Risk stratification and advancing precision therapy strategies for Oral Squamous Cell Carcinoma (OSCC) through the integration of Nanotechnology-enhanced Nutritional interventions with comprehensive Randomized controlled Trials: Exploring the Therapeutic potential of targeting Iron-Responsive Elements (IREs) and their binding proteins.

Indian Council of Medical Research DHRDepartment of Health Research New Delhi India1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年1月6日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
100
试验地点
1
主要终点
Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month

研究概览

简要总结

Oral Squamous Cell Carcinoma (OSCC) remains a significant global health challenge due to its aggressive nature and poor prognosis in advanced stages. Traditional therapeutic approaches often fall short in effectively addressing the heterogeneity and complexity of OSCC. To improve outcomes, there is a pressing need for strategies that offer precise risk stratification and tailored therapeutic interventions.

The trial seeks to advance precision therapy for OSCC by integrating cutting-edge nanotechnology-enhanced nutritional interventions within the framework of comprehensive randomised controlled trials (RCTs). Specifically, the trial will explore the therapeutic potential of targeting Iron-Responsive Elements (IREs) and their binding proteins, which play a critical role in cellular iron metabolism and have been implicated in cancer progression. By focusing on these molecular targets, the trial aims to develop more effective, personalized treatment strategies that could lead to better management and prognosis of OSCC.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded

入排标准

年龄范围
30.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • Non habit OSCC patients and healthy individuals.

排除标准

  • patient without habits.

结局指标

主要结局

Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month

时间窗: Overall Survival (OS), Progression-Free Survival (PFS) will be assessed at regular time intervals at baseline, 3rd month, 6 th month, 9th month and 12 th month

次要结局

  • Response Rate (RR), Quality of Life (QoL),Biomarker Response,(Safety and Tolerability)

研究者

发起方
Indian Council of Medical Research DHRDepartment of Health Research New Delhi India
申办方类型
Government funding agency
责任方
Principal Investigator
主要研究者

Hema Shree K

Saveetha Dental College, SIMATS

研究点 (1)

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