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临床试验/NCT04637659
NCT04637659已完成不适用

E. Faecalis Prevalence in Primary and Secondary Endodontic Infections: a Pre-post Microbial Analysis Following Chemo-mechanical Preparation

University of Siena1 个研究点 分布在 1 个国家目标入组 72 人开始时间: 2019年6月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
72
试验地点
1
主要终点
Prevalence of E.Faecalis in the canal before the treatment for each group

研究概览

简要总结

Post-treatment apical periodontitis is a fairly prevalent condition frequently caused by a persistent endodontic infection due to failure of the endodontic treatment. Microbial species in treated or untreated root canals were found to be different, with the former being less diverse and mainly characterized by Gram positive, facultative anaerobes bacteria than the latter. Enterococcus faecalis is the most frequently detected species in root-filled teeth in many studies (Zhang et al., 2015). In fact, E. Faecalis retains many virulence factors allowing adhesion to host cells and extracellular matrix, tissue invasion and damage through toxins release, as well as the ability to survive even in harsh environmental conditions. Further studies are needed to clarify E. faecalis prevalence among the different forms of pulpal and periapical lesions as well as its correlation with clinical symptoms.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Prevalence of E.Faecalis in the canal before the treatment for each group

时间窗: Pre-treatment microbial sampling in the canal was carried out 1 day once arrived at working length with a 10 K-file

E.Faecalis prevalence in the canal before the treatment will be calculated for each group.

次要结局

  • Correlation between E.Faecalis presence in the canal before the treatment and the pulpal/periapical status(Pre-treatment microbial sampling in the canal was carried out 1 day once arrived at working length with a 10 K-file)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nicola Discepoli

Professor

University of Siena

研究点 (1)

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