2025-521217-46-00RecruitingPhase 4
Impact of influenza vaccination on nasal resident memory immune responses and respiratory peripheral memory immune responses - MUCOVAC 2
Centre Hospitalier Universitaire De Saint Etienne1 site in 1 country30 target enrollmentStarted: December 2, 2025Last updated:
Trial Snapshot
- Phase
- Phase 4
- Status
- Recruiting
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Frequency of resident memory lymphocytes in the nasal mucosa and expression rate of migration markers towards the respiratory mucosa on peripheral memory lymphocytes before and after intramuscular influenza vaccination: variation in frequency between before and after vaccination
Study Overview
Brief Summary
To assess the impact of influenza vaccination on resident memory lymphocyte responses in the nasal mucosa and peripheral memory lymphocyte responses with respiratory tropism.
Eligibility Criteria
- Ages
- 18 years to 65+ years (18-64 Years, 65+ Years)
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Having decided to have a flu vaccination
- •Having signed the consent form for participation in the study
Exclusion Criteria
- •History of recurrent nosebleeds or systemic haemorrhages
- •Accident or surgery that altered the ENT sphere, including the nasal cavity
- •On anti-coagulant therapy
- •Severe respiratory infection in the last 6 months requiring hospitalisation
- •Immunosuppressed or on immunosuppressive therapy
- •Persons deprived of their liberty
- •Persons under guardianship or curatorship
- •Having received a vaccination in the last 30 days
- •Pregnant or breast-feeding women
Outcomes
Primary Outcomes
Frequency of resident memory lymphocytes in the nasal mucosa and expression rate of migration markers towards the respiratory mucosa on peripheral memory lymphocytes before and after intramuscular influenza vaccination: variation in frequency between before and after vaccination
Frequency of resident memory lymphocytes in the nasal mucosa and expression rate of migration markers towards the respiratory mucosa on peripheral memory lymphocytes before and after intramuscular influenza vaccination: variation in frequency between before and after vaccination
Secondary Outcomes
- The frequencies of resident memory T and B lymphocytes in the nasal cavity and the percentage of migration markers specific to the respiratory mucosa expressed on peripheral memory T and B lymphocytes.
- Correlation coefficients between the frequency of nasal resident memory lymphocytes, the percentage of migration markers expressed on peripheral memory lymphocytes, as well as anti-Influenza titers and Influenza neutralising antibody titers in mucosa and serum, the systemic cellular response specific to Influenza and the percentage of expression of genes involved in the systemic immune response.
Investigators
Elisabeth BOTELHO-NEVERS
Scientific
Centre Hospitalier Universitaire De Saint Etienne
Study Sites (1)
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