试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- expression of survivin in neoplastic and adjacent normal renal tissues
研究概览
简要总结
detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.
详细描述
renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients suffer from renal cell carcinomas
排除标准
- •patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.
结局指标
主要结局
expression of survivin in neoplastic and adjacent normal renal tissues
时间窗: april, 2021
Survivin is highly expressed in neoplastic renal tissues compared to normal ones by immunohistochemical measures..
次要结局
未报告次要终点
研究者
Maisa Hashem Mohammed
lecturer of pathology
Sohag University