Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma
Completed
- Conditions
- Renal Cell Carcinoma
- Registration Number
- NCT04873180
- Lead Sponsor
- Sohag University
- Brief Summary
detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.
- Detailed Description
renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- patients suffer from renal cell carcinomas
Exclusion Criteria
- patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method expression of survivin in neoplastic and adjacent normal renal tissues april, 2021 Survivin is highly expressed in neoplastic renal tissues compared to normal ones by immunohistochemical measures..
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Maisa Hashem Mohammed
🇪🇬Sohag, Egypt