NCT04460131招募中不适用
Association Between Soluble ST2 and Cardiovascular Outcome After Cardiovascular Surgery
Nanjing Medical University1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2019年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- All-cause mortality
研究概览
简要总结
Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant cardiovascular morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) is biomarker of myocardial remodeling and fibrosis; however, little is known regarding their potential association with cardiovascular events. This study aimed to investigate the release of sST2 and its association with cardiovascular events undergoing cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥ 18 years
- •Congenital heart disease requiring surgery
- •Valvular heart disease requiring surgery
- •Arrhythmia requiring surgery
- •Aortic dissection requiring surgery
- •Coronary heart disease requiring surgery
排除标准
- •age <18 years
- •pregnancy
- •severe renal dysfunction (creatinine >200µmol/L)
- •not capable of understanding or signing informed consent.
结局指标
主要结局
All-cause mortality
时间窗: 30 days after surgery
Number of participants death of 30 days after surgery
次要结局
- Heart failure(30 days after surgery)
研究者
Hong Liu
Investigator of Nanjing Medical University
Nanjing Medical University
研究点 (1)
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