Pilot Trial of the First Conversational Agent for Smoking Cessation (QuitBot)

Not Applicable

Completed

• Conditions: Smoking Cessation
• Interventions: Behavioral: Delayed access to novel novel messaging program intervention; Behavioral: Immediate access to novel messaging program intervention; Behavioral: Immediate access to standard of care messaging program intervention

• Registration Number: NCT03585231
• Lead Sponsor: Fred Hutchinson Cancer Center

Brief Summary

Conversational agents (CAs) are computer-powered digital coaches designed to form long-term social-emotional connections with users through conversations. We have developed a CA for cigarette smoking cessation. In a pilot randomized trial (N = 415), we will compare the experimental messaging program (n = 155) with the standard of care national government smoking cessation messaging program (n = 157), and then we will compare immediate (n=51) versus delayed (n=51) access to the the experimental messaging program, to assess 12-week usability, receptivity, and preliminary cessation results in adults in western Washington State and nationally across the US who want to quit smoking.

Detailed Description

Cigarette smoking is the most preventable cause of cancer in the US, accounting for one-third of all cancer deaths. Within the Fred Hutchinson Center's western Washington State 13-county catchment area, there are enormous disparities in adult cigarette smoking rates. Our recently completed WebQuit website RCT for smoking cessation had low engagement and no personalization to users' needs. Fortunately, a potentially game-changing solution to the problems of engagement and lack of personalization provide a new direction for my research. Advances in machine learning, natural language processing, and cloud computing are making it possible to create and widely disseminate conversational agents (CAs), which are computer-powered digital coaches designed to form long-term social-emotional connections with users through conversations. We have developed a CA for cigarette smoking cessation. In a pilot randomized trial (N = 415), we will compare the experimental messaging program with the standard of care national government smoking cessation messaging program, and then we will compare immediate versus delayed access to the the experimental messaging program. Twelve-week usability, receptivity, and preliminary cessation results will provide critical and timely pilot data.

Study Timeline

• Study First Submitted: 2018-06-29
• Study First Submitted QC: 2018-06-29
• Study First Posted: 2018-07-12
• Study Start: 2018-09-17
• Primary Completion: 2019-12-06
• Status Verified: 2020-12
• Study Completion: 2020-12-02
• Last Update Submitted: 2020-12-07
• Last Update Posted: 2020-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 404

Inclusion Criteria

• age 18 or older
• smokes at least five cigarettes daily for at least past 12 months
• wants to quit cigarette smoking in the next 14 days
• if concurrently using any other nicotine or tobacco products, wants to quit using them within the next 14days
• resides in western Washington State (in the following counties: Clallam, Grays Harbor, Island, Jefferson, King, Kitsap, Mason, Pierce, San Juan, Skagit, Snohomish, Thurston, and Whatcom)
• interested in learning skills to quit smoking
• willing to be randomly assigned to either condition
• has at least daily access to their own personal smartphone
• has and uses both text messaging and Facebook Messenger on their smartphone
• willing and able to read in English
• not using other smoking cessation interventions (including apps or our other intervention studies).
• willing to complete one 3-month follow-up survey
• willing to provide email, phone, and mailing address.

Exclusion Criteria

• The exclusion criteria are opposite of the inclusion criteria listed above.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Delayed Control	Delayed access to novel novel messaging program intervention	This is the second control arm of the study. This includes receiving the novel/experimental smoking cessation messaging program after completing the 3-month follow-up survey. Therapy description withheld to protect the integrity of the study.
Experimental	Immediate access to novel messaging program intervention	This is the experimental arm of the study. This includes receiving immediate access to the novel/experimental smoking cessation messaging program. Therapy description withheld to protect the integrity of the study.
Control	Immediate access to standard of care messaging program intervention	This is the control arm of the study. This includes receiving receiving immediate access to the standard of care smoking cessation messaging program. Therapy description withheld to protect the integrity of the study.

Primary Outcome Measures

Name	Time	Method
30-day point prevalence abstinence	3 months post randomization	No smoking in the past 30 days, as reported 3 month post treatment.

Trial Locations

Locations (1)

Fred Hutchinson Cancer Research Center; 🇺🇸 Seattle, Washington, United States