Comparison of the effect of ketorolac and intravenous lidocaine on fentanyl-induced cough in surgery
- Conditions
- Fentanyl induced Cough.Cough
- Registration Number
- IRCT20220102053599N1
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 210
aged 18 to 60 years, with and with, who
any gender
ASA 1 or 2
referred to Firoozgar and Hazrat Rasul-e Akram hospitals and are candidates for elective surgery that lasts more than an hour
in the period of April 2022 to June 2022
Preoperative pulmonary emphysema
Bronchial asthma
History of upper respiratory infection during the last 2 weeks
Smoking
Hypertension
Coronary artery disease
Has a chronic cough that makes it difficult to diagnose fentanyl-induced cough
High pressure inside the eyes, brain or abdomen
Taking anti-anxiety and anti-depressant drugs before surgery
Taking anti-cough medicines (codeine, dextromethorphan, baclofen, steroids or bronchodilators) during the last week
BMI above 28 kg/m2
History of chronic opioid use
Taking cough medicines (ACEI & ABR)
History of GERD or peptic ulcer
History of kidney or liver disease
Pregnancy or breastfeeding
Known allergy to fentanyl or ketorolac
G6PD deficiency disease
High risk of GIB
Patient reluctance
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cough. Timepoint: Within 90 seconds of fentanyl injection. Method of measurement: observation.
- Secondary Outcome Measures
Name Time Method Cough Intensity. Timepoint: Within 90 seconds of fentanyl injection. Method of measurement: Observation.;Cough start time. Timepoint: Within 90 seconds of fentanyl injection. Method of measurement: Stopwatch.