Tumor Immune Mechanism of Axillary Lymph Node Metastasis in Early Luminal Type A Breast Cancer

• Conditions: Luminal A; Immune Microenvironment; Lymph Node Metastases
• Interventions: Other: no intervention

• Registration Number: NCT04322331
• Lead Sponsor: Peking University People's Hospital

Brief Summary

Luminal type A breast cancer is a type with good clinical prognosis, and the proportion of lymph node metastasis is low, but a small number of patients have more lymph node metastasis when the primary tumor is very small, and the survival is poor, suggesting that this part of Luminal A breast cancer has the different expression of some genes from that of general Luminal A breast cancer, which affects tumor invasion and participates in the occurrence of tumor metastasis. But the mechanism is not clear, especially in the current tumor microenvironment and immune related mechanisms.We want to investigated the relationship of the transcriptional tumor immune microenvironment with early lymph node metastasis among Luminal A type breast cancer.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-03
• Study First Submitted: 2020-03-24
• Study First Submitted QC: 2020-03-24
• Study First Posted: 2020-03-26
• Last Update Submitted: 2020-03-27
• Last Update Posted: 2020-03-31
• Study Start: 2020-05-01
• Primary Completion: 2021-05-01
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

• invasive breast cancer with Luminal A type;T1 with positive lymph node or T2/T3 with negative lymph node

Exclusion Criteria

• Missing specimen

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
T1N+	no intervention	T1 tumor with positive lymph node,N1/N2/N3
T2/T3N0	no intervention	T2/T3 tumor with negative lymph node

Primary Outcome Measures

Name	Time	Method
Transcriptional Characterization	2020-12	the relationship of the transcriptional tumor immune microenvironment with lymph node metastases in Luminal A breast tumor;Differences in RNA copy numbers of different genes （using IO Panel） between the two groups of patients

Trial Locations

Locations (1)

Peking university people's hospital; 🇨🇳 Beijing, China