Psychological Intervention and Physiotherapy With Medication Improves CRPS Patients Outcome
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Direction of change in patient reported CRPS symptom discriptors
研究概览
简要总结
A ten week open label study intervention to evaluate the outcome for a psychological intervention combined with physiotherapy and medication with memantine-morphine in 10 CRPS patients.
详细描述
Ten CRPS I patients attended an intervention for 10 weeks. First, the medication was started with morphine 10mg adding gradually to 30 mg per day. Then, in addition to morphine, memantine 5 mg was started adding the dose gradually up to 40 mg per day if tolerated. Physiotherapy and psychological intervention were mostly carried out in a weekly group gathering with home exercises that were recorded to a diary. Psychological and physiotherapy interventions lasted for eight weeks. A neurological examination was done before and after the intervention as well as a separate physiotherapist examination of the hands. Patients filled out questionnaires of mood, quality of life, pain, and CRPS descriptions before and after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •CRPS type 1 for at least 6 months,
- •pain NRS 4 or more
排除标准
- •major psychiatric or neurological disease
研究组 & 干预措施
intervention
Open label study with psychological intervention and physiotherapy intervention with medication of morphine, memantine for ten weeks (morphine 30mg tbl per day and memantine up to 40mg tbl per day if tolerated).
干预措施: Morphine, memantine (Drug)
intervention
Open label study with psychological intervention and physiotherapy intervention with medication of morphine, memantine for ten weeks (morphine 30mg tbl per day and memantine up to 40mg tbl per day if tolerated).
干预措施: Psychological intervention (Behavioral)
intervention
Open label study with psychological intervention and physiotherapy intervention with medication of morphine, memantine for ten weeks (morphine 30mg tbl per day and memantine up to 40mg tbl per day if tolerated).
干预措施: Physiotherapy intervention (Other)
结局指标
主要结局
Direction of change in patient reported CRPS symptom discriptors
时间窗: Three months
Reports of CRPS symptoms
次要结局
- Direction of change in motor parameters(Three months)
- Direction of change in psychological parameters(Three months)
- Direction of change in quality of life(Three months)
研究者
Hanna Harno
MD, PhD
Helsinki University Central Hospital