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临床试验/NCT04873882
NCT04873882Unknown不适用

Waveform and Spectral Characteristics of Perioperative Wheezing

University of Virginia1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2019年12月16日最近更新:
适应症

试验速览

阶段
不适用
入组人数
40
试验地点
1
主要终点
Spectral Waveform Analysis to discriminate between wheezing and not wheezing based on specific frequency bands

研究概览

简要总结

With the aid of computerized sound analysis, digital acoustic monitoring could provide a more sensitive, specific, and quantifiable indicator for perioperative respiratory abnormalities including wheezing. It is probable that the digital stethoscope has utility in the detection, monitoring, and resolution following treatment of acoustic changes characteristic of turbulent respiratory gas flow due to wheezing and/or the incomplete resolution of atelectasis following the re-initiation of ventilation in a collapsed lung.

详细描述

Anesthesiologists still rely on use of a conventional stethoscope to detect abnormal breath sounds during and after surgery - this process is labor intensive, intermittent, relies on human experience and thus is highly subjective. In fact, even for the most basic assessments, e.g. endobronchial intubation, human auscultation is unreliable.1 Digital stethoscopes are able to both amplify and digitize airway sounds and also provide a mechanism to record and analyze them for features undetectable by a human. Several small, pilot studies have shown that acoustic waveforms from the lungs produce characteristic spectral patterns in specific pulmonary pathophysiologic states. At this time, there are no studies that examine the acoustic patterns specific to perioperative wheezing or lung re-expansion. With the aid of computerized sound analysis, digital acoustic monitoring could provide a more sensitive, specific, and quantifiable indicator for perioperative respiratory abnormalities including wheezing. It is probable that the digital stethoscope has utility in the detection and monitoring of acoustic changes characteristic of turbulent respiratory gas flow due to wheezing and/or the incomplete resolution of atelectasis following the re-initiation of ventilation in a collapsed lung. In addition, treatment of perioperative wheezing with an inhaled bronchodilator may lead to resolution of wheezing and this response to treatment may also be monitored using waveform and spectral characteristics of the acoustic patterns from the digital stethoscope.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients scheduled for either:
  • open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring one-lung ventilation
  • abdominal surgery with a known history of chronic obstructive pulmonary disease (as documented in the electronic medical record)

排除标准

  • Emergency surgery
  • surgery requiring the use of transesophageal echocardiography
  • refusal of informed consent
  • pregnancy
  • esophageal surgery
  • lung transplantation
  • contraindications for placement of esophageal stethoscope including esophageal varices strictures, motility disorders, diverticula or a history of prior esophageal injury or surgery
  • age less than 18 years old

结局指标

主要结局

Spectral Waveform Analysis to discriminate between wheezing and not wheezing based on specific frequency bands

时间窗: Duration of the operation while the esophageal stethoscope is in place, an average of 3 hours

Comparison of the spectral waveforms to determine the specific frequency bands associated with wheezing and non-wheezing

次要结局

  • Spectral waveform analysis associated with ventilatory parameters(Duration of the operation while the esophageal stethoscope is in place, an average of 3 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Allison Bechtel, MD

Assistant Professor of Anesthesiology

University of Virginia

研究点 (1)

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