NCT05473637招募中不适用
Deciphering, Construction and Validation of Magnetic Resonance Imaging Maps, Clinical Features and Outcomes in Genetic and Nongenetic Cerebral Small Vessel Diseases
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Number of patients with incident stroke
研究概览
简要总结
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must have at least one of the following symptoms/signs or history
- •stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke)
- •cognitive impairment or dementia
- •gait disturbance
- •parkinsonism (especially vascular parkinsonism features)
- •headache (especially migraine)
- •positive family history of hereditary CSVD
- •MRI evidence of CSVD (MRI may be done for other reasons), including mild to moderate white matter hyper intensity, any lacune, or any cerebral microbleed
排除标准
- •MRI evidence of CSVD due to other inflammatory, malignancy, or structural lesions
- •patients or family members not willing to sign informed consent
结局指标
主要结局
Number of patients with incident stroke
时间窗: 2 years
Clinical stroke, including transient ischemic attack, ischemic stroke, or intracerebral hemorrhage. The stroke is defined by a focal neurological deficits lasting more than 24 hours, with accompanied neuroimaging evidence of infarct or hemorrhage in corresponding brain area.
次要结局
- Number of patients with incident dementia(2 years)
研究者
研究点 (1)
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