Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia

Completed

• Conditions: Invasive Fungal Infection; Acute Leukemia
• Interventions: Biological: blood sample

• Registration Number: NCT02823132
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.

Detailed Description

Not available

Study Timeline

• Primary Completion: 2015-06
• Status Verified: 2016-06
• Study First Submitted: 2016-06-29
• Study First Submitted QC: 2016-07-05
• Last Update Submitted: 2016-07-05
• Study First Posted: 2016-07-06
• Last Update Posted: 2016-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 134

Inclusion Criteria

Not provided

Exclusion Criteria

• Patients who have received an bone marrow PSC allograft (as such patients have a risk of aspergillosis, which appears in most cases after medullar recovery; they will not be included in the study).
• Patients who have received an autologous PSC graf (as the duration of neutropenia is in most cases less than 10 days).
• Patients whose neutropenia, retrospectively assessed, lasted less than 10 days.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients without fungal infection	blood sample	-
patients who develop a fungal infection	blood sample	-

Primary Outcome Measures

Name	Time	Method
serum level of Mannose Binding Lectin (MBL) in patients with acute leukemia	1st day of the period of aplasia

Secondary Outcome Measures

Name	Time	Method
Serum levels of MBL during an episode of aplasia for both groups of patients studied	Every day except Saturday and Sunday for roughly 3 weeks

Trial Locations

Locations (1)

Centre Hospitalier Universitaire; 🇫🇷 Dijon, France