Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation
研究概览
简要总结
The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change
详细描述
The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment [aMCI] or light cognitive confusion of type amnestic)
- •The patient must be affiliated to an insurance scheme disease to participate in this study
排除标准
- •For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc.
- •Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders
- •Appointment of a guardian
研究组 & 干预措施
2
40 patients before hand include in a program
干预措施: Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA (Other)
1
Subject control
干预措施: Neurological and neuropsychological consultation, MRI (Other)
结局指标
主要结局
Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation
时间窗: 36 months
Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement.
时间窗: 36 months
Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis
时间窗: 36 months
Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement.
时间窗: 36 months
Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old.
时间窗: 36 months
次要结局
- Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY.(36 months)
- Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible.(36 months)
- Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease.(36 months)
- Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease.(36 months)
- Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve.(36 months)