Short- and Long-term Health Effects of Air Pollution in Poland

Active, not recruiting

• Conditions: Acute Coronary Syndrome; Atrial Fibrillation; Particulate Matter Inhalation Injury; Pollution; Exposure; Kidney Diseases; Ischemic Stroke; Oxidative Stress

• Registration Number: NCT05198492
• Lead Sponsor: Medical University of Bialystok

Brief Summary

The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack of large industry). The aim of the project is to assess the impact of air pollution in Eastern Poland on regional public health.

Detailed Description

The project will be conducted in Eastern Poland - the area characterized by unique natural features, large areas covered by forests, lack of factories, and relatively low industrialization. On the other hand, the region is also characterized by low socioeconomic status, in the cold season the residents' suboptimal heating choices are in result posing a major anthropogenic threat to air quality in the form of low emissions. The vast majority of studies on air pollution were conducted in highly polluted areas, in which patients are exposed to moderate and extreme concentrations of pollutants. Taking into consideration the scarce number of surveys from areas with a low level of pollution the investigators intend to analyze the relationship between air pollution and cardiovascular and renal outcomes in Eastern Poland. The examination of the impact of so-called "Polish smog" on mortality and morbidity in the study area is not without significance. It would be the first major study of the impact of this type of pollution on human health.

In the subsequent part of the study, we will evaluate the effects of Polish smog in the entire country.

In light of extant body of literature, the following will be considered as the public health indicators: acute coronary syndromes, episodes of atrial fibrillation, ischemic strokes, kidney disease hospitalizations or emergency room visits, cardiovascular and renal mortality.

Study Timeline

• Study Start: 2011-01-01
• Primary Completion: 2020-12-31
• Study First Submitted: 2022-01-06
• Study First Submitted QC: 2022-01-06
• Study First Posted: 2022-01-20
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-18
• Last Update Posted: 2024-06-21
• Study Completion: 2030-12-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 8300000

Inclusion Criteria

• Residents from the analyzed area

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of hospitalizations due to kidney diseases related to the impact of air pollution.	Through study completion, an average of 1 year	Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Number of atrial fibrillation episodes related to the impact of air pollution.	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on the number of hospital admissions for atrial fibrillation.
Number of hospitalizations due to acute kidney diseases related to the impact of air pollution.	Through study completion, an average of 1 year	Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Number of patients under hemodialysis related to the impact of air pollution.	Through study completion, an average of 1 year	Long- term influence of air pollution on the number of hospital admissions for kidney disease.
Number of acute coronary syndromes related to the impact of air pollution.	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on the number of hospital admissions for acute coronary syndromes.
Number of ischemic strokes related to the impact of air pollution.	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on the number of hospital admissions for ischemic strokes.

Secondary Outcome Measures

Name	Time	Method
Neoplasm mortality	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on neoplasm mortality.
Cardiovascular mortality	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on the number of cardiovascular mortality.
Kidney disease mortality	Through study completion, an average of 1 year	Short- and long- term influence of air pollution on mortality related to renal function.

Trial Locations

Locations (1)

Department of Invasive Cardiology, Medical University of Bialystok; 🇵🇱 Białystok, Podlaskie, Poland