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Clinical Trials/NCT00653809
NCT00653809
Completed
Not Applicable

Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies

University of Mississippi Medical Center1 site in 1 country52 target enrollmentJune 2007
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ConditionsPreeclampsia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Preeclampsia
Sponsor
University of Mississippi Medical Center
Enrollment
52
Locations
1
Primary Endpoint
Nitric oxide and Endothelin-1 levels
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.

Registry
clinicaltrials.gov
Start Date
June 2007
End Date
September 2009
Last Updated
14 years ago
Study Type
Observational
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Kedra Wallace

Postdoc Research Fellow

University of Mississippi Medical Center

Eligibility Criteria

Inclusion Criteria

  • •African-american or Caucasian
  • •Between ages of 18 - 40 years of age

Exclusion Criteria

  • •Presence of a disease or condition which is not preeclampsia
  • •Drug or alcohol abuse during pregnancy

Outcomes

Primary Outcomes

Nitric oxide and Endothelin-1 levels

Time Frame: 48 hours after tissue collection

Secondary Outcomes

  • Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome(within 6 months from tissue collection)

Study Sites (1)

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