NCT00653809CompletedNot Applicable
Elucidating the Role of Nitric Oxide and Endothelin-1 Activation in Endothelial Cells Co-cultured With Placental Explants From African-american and Caucasian High Risk Pregnancies
University of Mississippi Medical Center1 site in 1 country52 target enrollmentStarted: June 2007Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Nitric oxide and Endothelin-1 levels
Study Overview
Brief Summary
The goal of this study is to examine the activation of markers of endothelial and cardiovascular dysfunctions, from women with high-risk pregnancies. Information from this study will hopefully provide enough information to determine a link between race, the advent of high risk pregnancies and cardiovascular markers. With this information it might be possible to intervene with approved pharmacological treatments.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •African-american or Caucasian
- •Between ages of 18 - 40 years of age
Exclusion Criteria
- •Presence of a disease or condition which is not preeclampsia
- •Drug or alcohol abuse during pregnancy
Outcomes
Primary Outcomes
Nitric oxide and Endothelin-1 levels
Time Frame: 48 hours after tissue collection
Secondary Outcomes
- Nitric oxide isoforms and Endothelin-1 receptor activation based on primary outcome(within 6 months from tissue collection)
Investigators
Kedra Wallace
Postdoc Research Fellow
University of Mississippi Medical Center
Study Sites (1)
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