Validation of the "Exspiron©" in Patients With Amyotrophic Lateral Sclerosis; Non-invasive Monitoring of Respiratory Volume.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 主要终点
- The validity of the respiratory volumes (tidal volume and minute volume), compared tot the pneumotachometer.
研究概览
简要总结
Non-invasive ventilation (NIV) in patients diagnosed with amyotrophic lateral sclerosis (ALS) is nowadays common practice to provide comfort at the end stage of the disease. As complaints vary there is the need of a non-invasive device to measure respiratory volume to objectify complaints.
The ExSpiron© is a device for non-invasive monitoring of respiratory volume. The validation of this monitor in patients with ALS is the aim of this study.
The hypothesis is that the ExSpiron© delivers a valid assessment of respiratory volume in patients with ALS
详细描述
Rationale: Non-invasive ventilation (NIV) in patients diagnosed with amyotrophic lateral sclerosis (ALS) is nowadays common practice to provide comfort at the end stage of the disease. As complaints vary there is the need of a non-invasive device to measure respiratory volume to objectify complaints.
The ExSpiron© is a device for non-invasive monitoring of respiratory volume. The validation of this monitor in patients with ALS is the aim of this study.
The hypothesis is that the ExSpiron© delivers a valid assessment of respiratory volume in patients with ALS Objective: The primary objective is the validation of the ExSpiron© non-invasive monitor in patients diagnosed with ALS.
Study design: This is an intervention study The validation of the ExSpiron© in patients diagnosed with ALS is done during admission on the Respiratory Care Unit (RCU) of the University Medical Center Groningen (UMCG). At daytime, tidal volume (TV) and minute volume (MV) will be measured during spontaneous breathing with the ExSpiron© simultaneously with a pneumotachometer (gold-standard). After installation of the chest pad of the ExSpiron© and the pneumotachometer, the first measurements are in sitting position. Three complete cycles of ten breaths; normal breathing, slow-deep breathing and rapid-shallow breathing, will be done. Between each cycle, a pause is allowed. After completing this breathing sequence, it is repeated in supine position. If patients are not able to perform this in supine position, because of orthopnea, an angle of 45º degree is adequate. After completing this cycle, the chest pad should be left in place and the electromyography (EMG) equipment should be installed. During the first night of admission, a full night of measurement of TV and MV will be conducted using the ExSpiron©.
Study population: 10 patients diagnosed with ALS and an indication to start NIV, >18 years of age.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In order to be eligible to participate in this study, a subject must meet all of the following criteria:
- •Participants diagnosed with ALS requiring NIV
- •Age > 18 of age; < 85 years of age
- •An indication to start chronic NIV, hypercapnic respiratory failure (arterial carbon dioxide PaCO2 > 6.0 kilo pascal (kPa) measured during daytime) or orthopnoea due to diaphragm paralysis.
- •Participants are able to provide feedback
- •Participants that are willing to participate and are able to consent and sign the informed consent form.
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •Clinically unstable
- •Acute respiratory failure
- •Participants with refractory hypotension, defined as systolic blood pressure less than 90 mmHg, despite inotropic agents
- •Uncontrolled cardiac ischemia or arrhythmias
- •Participants suffering from metastatic or terminal cancer
- •Other comorbid disease affecting respiration (ie obstructive sleep apnea, chronic obstructive pulmonary disease)
- •Participants lacking functional medical decision-making
结局指标
主要结局
The validity of the respiratory volumes (tidal volume and minute volume), compared tot the pneumotachometer.
时间窗: 1 year
The validation of the ExSpiron© non-invasive monitor in patients diagnosed with ALS.
次要结局
- The BORG RPE score (Ratings of Percieved Exertion)(1 year)
- The Amyotrophic lateral Sclerosis Assessment Questionnaire (ALSAQ-40)(1 year)
- SenTec is the name of a transcutaneous monitor(1 year)
- The EMG(1 year)
研究者
Peter Wijkstra
Principal Investigator P.J. Wijkstra
University Medical Center Groningen