Tailor-CRT: Better application of Cardiac Resynchronization Therapy by automated and improved selection of location and timing of stimulatio

Completed

Conditions: Heart Failure
10019280

Registration Number: NL-OMON40325

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

The study population consists of patients referred for CRT implantation, who have a class I indication for CRT according to current international guidelines. The patients will be recruited from the out-patient Pacemaker/ICD clinic and from the cardiology ward. ;
* Chronic heart failure with NYHA functional class II-IV
* Left ventricular ejection fraction (LVEF) < 35%
* Left bundle-branch block (LBBB) with QRS duration > 120 ms
* In sinus rhythm

Exclusion Criteria

* Atrial fibrillation
* >=4 premature ventricular complexes on standard 12-lead ECG
* Age <18 years or > 80 years
* Incapable of giving informed consent
* Moderate to severe aortic valve stenosis

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study endpoints<br /><br><br /><br>* Agreement between the increase in LVdP/dtmax obtained at the optimal AV- and<br /><br>VV-interval as predicted by D-VCG and the largest increase in LVdP/dtmax during<br /><br>hemodynamic evaluation of AV- and VV-intervals.<br /><br><br /><br>* Agreement between the increase in LVdP/dtmax obtained at the optimal LV lead<br /><br>position as predicted by VCG and LVLED and the largest increase in LVdP/dtmax<br /><br>during hemodynamic evaluation of potential LV lead positions. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study endpoint:<br /><br><br /><br>* Agreement between QRS vector area, -angle and -amplitude on VCG with that on<br /><br>D-VCG. </p><br>