Clinical Observation of Titration Induction and Convention Induction of Propofol

Not Applicable

Completed

• Conditions: Propofol Overdose of Undetermined Intent
• Interventions: Procedure: titration induction to propofol

• Registration Number: NCT02199522
• Lead Sponsor: Lihong Chen

Brief Summary

As we know propofol is popular use in the anesthesia induction with kilogram and it always cause hypotension. So we compare haemodynamic changes and drug consumption between propofol titrated administration and traditional administration for anesthesia induction.

Detailed Description

GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min, GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to 1, then changed to a maintenance dose

Study Timeline

• Study First Submitted: 2014-07-22
• Study First Submitted QC: 2014-07-22
• Study First Posted: 2014-07-24
• Study Start: 2014-07-28
• Primary Completion: 2014-11-30
• Study Completion: 2014-11-30
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-19
• Last Update Posted: 2020-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Patients with American Society of Anesthesiologists(ASA)Ⅰor Ⅱ and aged 18-60 yr, who were scheduled for general anesthesia.

Exclusion Criteria

• Hypertension, Severe heart,pulmonary,brain，liver and renal dysfunction; excess obesity , predicted difficult intubation,hearing obstacles;. Allergic to propofol or its fat emulsion;addictive to sedative and other drugs.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
titration induction of propofol	titration induction to propofol	titration induction of propofol by Fresenius pump at the speed of 1 mg•kg-1•min-1

Primary Outcome Measures

Name	Time	Method
systolic pressure diastolic pressure mean blood pressure	15minutes	before propofol dosage ,1 min after the propofol dosage, 3 min , 5 min; , endotracheal intubation done immediately,1 min,3 min,5 min,7 min,9 min after endotracheal intubation

Secondary Outcome Measures

Name	Time	Method
total dosage of propofol using	15 minutes

Trial Locations

Locations (1)

Department of Anesthesia ,Sixth Affiliated hospital of Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China