Clinical Observation of Titration Induction and Convention Induction of Propofol
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Propofol Overdose of Undetermined Intent
- Sponsor
- Lihong Chen
- Enrollment
- 160
- Locations
- 1
- Primary Endpoint
- systolic pressure diastolic pressure mean blood pressure
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
As we know propofol is popular use in the anesthesia induction with kilogram and it always cause hypotension. So we compare haemodynamic changes and drug consumption between propofol titrated administration and traditional administration for anesthesia induction.
Detailed Description
GroupⅠreceived propofol 2 mg/kg intravenously by Fresenius pump at the speed of 250 mg/min, GroupⅡreceived propofol intravenously by Fresenius pump at the speed of 1 mg/kg/min, and observe's assessment of alertness and sedation(OAA/S) scale of the patients was titrated to 1, then changed to a maintenance dose
Investigators
Lihong Chen
Department of Anesthesia ,Sixth Affiliated hospital of Sun Yat-sen University
Sixth Affiliated Hospital, Sun Yat-sen University
Eligibility Criteria
Inclusion Criteria
- •Patients with American Society of Anesthesiologists(ASA)Ⅰor Ⅱ and aged 18-60 yr, who were scheduled for general anesthesia.
Exclusion Criteria
- •Hypertension, Severe heart,pulmonary,brain，liver and renal dysfunction; excess obesity , predicted difficult intubation,hearing obstacles;. Allergic to propofol or its fat emulsion;addictive to sedative and other drugs.
Outcomes
Primary Outcomes
systolic pressure diastolic pressure mean blood pressure
Time Frame: 15minutes
before propofol dosage ,1 min after the propofol dosage, 3 min , 5 min , endotracheal intubation done immediately,1 min,3 min,5 min,7 min,9 min after endotracheal intubation
Secondary Outcomes
- total dosage of propofol using(15 minutes)