Dexamethasone-induced Hiccup in Chemotherapy Patients Treated by Methylprednisolone Rotation
Phase 3
Completed
- Conditions
- Dexamethasone-induced Hiccup in Chemotherapy
- Interventions
- Registration Number
- NCT01974024
- Lead Sponsor
- Chung-Ang University
- Brief Summary
The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
- Detailed Description
we planned a randomized prospective trial for cancer patients with DIH. The objective of the present study was to determine whether the rotation of corticosteroids affects the incidence and intensity of DIH without compromising the antiemetic efficacy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
- all solid cancer patients on chemotherapy
- age >18 years
- received dexamethasone as an antiemetic
Exclusion Criteria
- brain metastases
- hiccups before dexamethasone administration
- uncontrolled diabetes mellitus
- uncontrolled esophagitis or peptic ulcer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Dexamethasone methylprednisolone Dexamethasone was re-administered in the cycle. Methylprednisolone methylprednisolone Dexamethasone was replaced with methylprednisolone as an antiemetic.
- Primary Outcome Measures
Name Time Method The intensities of hiccups 2 months Clinically assessed every cycles(2-4weeks). The intensities of hiccups were assessed using a NRS.
- Secondary Outcome Measures
Name Time Method The intensities of emesis 2 months CLinically assessed every cycles (2-4weeks) The intensities of emesis were assessed using a NRS.
Trial Locations
- Locations (2)
Chungang University Hospital
🇰🇷Dongjak-gu, Seoul, Korea, Republic of
Gyeongsang National University Hospital
🇰🇷Chiram-dong, Jinju-si, Gyeongsangnam-do, Korea, Republic of