Effect of Intracameral Steroids Injection During Phacoemulsification on Postoperative Corneal Edema and Corneal Endothelium
Overview
- Phase
- Phase 3
- Intervention
- Control group
- Conditions
- Corneal Edema
- Sponsor
- Cairo University
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- Central corneal thickness (CCT)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids.
Intracameral steroids at the conclusion of phacoemulsification significantly improved corneal edema and spared corneal endothelium.
Detailed Description
Purpose: Investigating the effect of intracameral steroids at the end of phacoemulsification on corneal edema and endothelial count. Methods: Prospective, interventional case control study. Sixty-nine eyes were randomized into 3 groups, 23 eyes each : 2groups received intracameral dexamethasone and triamcinolone (TA) respectively, while controls didn't receive any intraoperative steroids. On the first postoperative day corneal edema in control compared to dexamethasone and TA groups respectively. One month later, the mean increase of corneal thickness in control compared to intracameral dexamethasone and TA groups, respectively. mean endothelial cell loss in control compared to intracameral dexamethasone and TA groups respectively.
Investigators
khaled gamal abueleinen
professor
Cairo University
Eligibility Criteria
Inclusion Criteria
- •Cataract grades 2 to 5 nuclear cataract (LOCS III scale)
- •uneventful phacoemulsification operation
Exclusion Criteria
- •extremely hard cataract grade 6 nuclear cataract (LOCS III scale)
- •soft cataract
- •subluxated lenses or zonular dehiscence
- •associated ocular pathology such as glaucoma
- •any signs of uveitis
- •retinal detachment
- •vitrectomized or silicone filled eyes
- •corneal disease such as Fuch's dystrophy, corneal opacity
- •previous refractive corneal surgery
- •Cases that developed ruptured posterior capsule and vitreous loss
Arms & Interventions
Control group 1
23 eyes that did not receive any intraoperative steroids
Intervention: Control group
Dexamethasone group 2
23 eyes that received intracameral dexamethasone
Intervention: Dexamethasone group
Triamcinolone (TA) group 3
23 eyes that received intracameral triamcinolone (TA)
Intervention: Triamcinolone (TA) group
Outcomes
Primary Outcomes
Central corneal thickness (CCT)
Time Frame: Three months
Central corneal thickness in microns after phacoemulsification that was compared to preoperative values
Endothelial cell loss
Time Frame: Three months
Corneal endothelial cell count (cell/ square mm) after phacoemulsification that was compared to preoperative values
Corneal edema
Time Frame: First day postoperative
Clinical grade of corneal edema on the first postoperative day
Secondary Outcomes
- IOP(Three months)