Topographical patterns of cerebral microbleeds in acute ischemic stroke subtypes and its association with cognition and risk factors of stroke
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 319
- 试验地点
- 1
- 主要终点
- To Determine the prevalence and topographic patterns of cerebral microbleeds in subtypes of acute ischemic stroke
研究概览
简要总结
The study will be conducted in the Department of Neurology Kasturba Medical College and Kasturba Hospital, Manipal. Patients who fulfill the inclusion criteria mentioned above will be approached. Eligible patients will be explained in detail about the study in their best understandable language and given a participant information sheet. Informed consent will be taken from participants who are willing to participate in the study after fully understanding the nature of the study and its risks/benefits. For patients who present with acute ischemic stroke General physical examination and detailed neurological examination will be conducted. Stroke severity will be assessed by NIHSS and stroke classified as per TOAST classification. Montreal Cognitive Assessment Score will be employed to assess cognitive status. Necessary blood investigations in consenting patients will be sent. MRI imaging of the patients will be accessed and the Cerebral microbleeds will be evaluated and quantified. A standard data collection proforma is designed to collect the above-mentioned information on demographic profiles, other associated symptoms, risk factors, and general and systemic examinations. All the proformas employed for testing are freely available. There will be no risk in the study as no additional tests are performed and only standard-of-care tests and procedures will be followed. Parameters recorded in the study are part of routine clinical care of the acute ischemic stroke protocol.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All adults more than 18 years of age presenting with acute ischemic stroke of less than 24 hours duration.
排除标准
- •Patients with neoplasms, intracranial surgery, traumatic brain injury, thrombocytopenia, bleeding diathesis, venous hemorrhagic infarcts and metallic implants insitu which is contraindication for MRI brain.
结局指标
主要结局
To Determine the prevalence and topographic patterns of cerebral microbleeds in subtypes of acute ischemic stroke
时间窗: To Determine the prevalence and topographic patterns of cerebral microbleeds in subtypes of acute ischemic stroke at the index admission within 24 hours | To compare the vascular risk factors, white matter lesion load, prior antiplatelet or anticoagulant use in patients with and without cerebral microbleeds at the index admission within 24 hours | Evaluate the scores of MoCA in patients of acute ischemic stroke with and without cerebral microbleeds at the index admission within 24 hours
To compare the vascular risk factors, white matter lesion load, prior antiplatelet or anticoagulant use in patients with and without cerebral microbleeds
时间窗: To Determine the prevalence and topographic patterns of cerebral microbleeds in subtypes of acute ischemic stroke at the index admission within 24 hours | To compare the vascular risk factors, white matter lesion load, prior antiplatelet or anticoagulant use in patients with and without cerebral microbleeds at the index admission within 24 hours | Evaluate the scores of MoCA in patients of acute ischemic stroke with and without cerebral microbleeds at the index admission within 24 hours
Evaluate the scores of MoCA in patients of acute ischemic stroke with and without cerebral microbleeds
时间窗: To Determine the prevalence and topographic patterns of cerebral microbleeds in subtypes of acute ischemic stroke at the index admission within 24 hours | To compare the vascular risk factors, white matter lesion load, prior antiplatelet or anticoagulant use in patients with and without cerebral microbleeds at the index admission within 24 hours | Evaluate the scores of MoCA in patients of acute ischemic stroke with and without cerebral microbleeds at the index admission within 24 hours
次要结局
- To evaluate the presence of hemorrhagic transformation after thrombolysis in patients with & without cerebral microbleeds(To evaluate the presence of hemorrhagic transformation after thrombolysis in patients with & without cerebral microbleeds within 24 hours of thrombolysis)
研究者
Dr Dandapantula Sushrutha
Manipal Academy of Higher Education