Comparing the efficacy of Propofol and Dexmedetomidine in controlling painful stress while skull pin insertion, used for position of head during brain tumor surgeries. propofol and dexmedetomidine are drugs used for starting of anaesthesia and maintaining blood pressure,heart rate during surgery"

Not yet recruiting

• Conditions: Benign neoplasm of brain, unspecified,

• Registration Number: CTRI/2021/03/031948
• Lead Sponsor: Dr Ramya Varda

Brief Summary

This current study is a Randomised, double blinded, parallel group, prospective single centric study to observe whether Propofol is better than Dexmedetomidine in abating metabolic stress and provide optimum adequate depth of anaesthesia by monitoring the blood glucose levels, an indirect marker of metabolic stress during the skull pin insertion. Skull pin insertion is rather a painful stimulus to the patient and demands adequate optimisation of hemodynamics.

The primary outcome isto compare the effects of  Propofol infusion and dexmedetomidine infusion on blood glucose levels during skull pin insertion

Secondary outcome is to observe the hemodynamic response after Propofol infusion and Dexmedetomidine infusion during skull pin insertion

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-18
• Last Update Posted: 2021-11-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• All patients who have given consent for the study 2.Patients posted for elective intracranial tumor surgeries 3.
• ASA Grade 1 & 2 4.Age 18-60 years.

Exclusion Criteria

1.Known history of allergies to Propofol, Dexmedetomidine 2.Baseline Heart rate <60 3.Known cases of heart block 4.Known cases of Coronary Artery Disease 5.Known case of Diabetes mellitus type 2, hypertension, pregnancy 6.Previous craniotomy incision 7.Emergency Operations 8.ASA Grade 3 and 4 9.Patients on steroids, psychoactive medications, alpha 2 agonists or antagonists, beta blockers 10.Patients with any known endocrine disorders 11.Patients with hepatic impairment 12.Difficult intubation or repeated attempts of intubation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
compare the effects of propofol infusion and dexmedetomidine infusion on blood glucose levels	baseline (pre operative) | 0 min (just before pin insertion) | 20 min after pin insertion | 40 min after pin insertion

Secondary Outcome Measures

Name	Time	Method
The hemodynamic response after propofol infusion and dexmedetomidine infusion	Baseline (pre operative)

Trial Locations

Locations (1)

Institute Of Medical Sciences and SUM Hospital; 🇮🇳 Khordha, ORISSA, India

Institute Of Medical Sciences and SUM Hospital

🇮🇳Khordha, ORISSA, India

Dr Ramya Varda

Principal investigator

9849240405

ramyavarda@gmail.com