Impact of a Non-Drug Choice on Cocaine Reinforcement
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
研究概览
简要总结
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate self-administration procedures and a non-drug alternative reinforcer, which is hypothesized to reduce the reinforcing effects of cocaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cocaine dependence, otherwise healthy
排除标准
- •Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease
研究组 & 干预措施
Low Value Alternative Reinforcer
A low value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Cocaine (Drug)
Low Value Alternative Reinforcer
A low value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Placebo (Drug)
Medium Value Reinforcer
A medium value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Cocaine (Drug)
Medium Value Reinforcer
A medium value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Placebo (Drug)
High Value Reinforcer
A high value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Cocaine (Drug)
High Value Reinforcer
A high value reinforcer will be made available as an alternative to cocaine and placebo.
干预措施: Placebo (Drug)
结局指标
主要结局
The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative
时间窗: 9 choice trials per cocaine dose level with each trial separated by 30 minutes
The reinforcing effects of cocaine were determined using a modified progressive ratio procedure in which subjects made 9 choices between each available cocaine dose and one of three money alternatives.
次要结局
未报告次要终点
研究者
Joshua A. Lile, Ph.D.
Joshua A. Lile, Ph.D., Associate Professor of Behavioral Science
University of Kentucky