Preventive and Personalized Medicine (2021-2023)

Asfendiyarov Kazakh National Medical University1 site in 1 country500 target enrollmentMarch 30, 2022

ConditionsIdiopathic Osteoarthritis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Idiopathic Osteoarthritis
Sponsor: Asfendiyarov Kazakh National Medical University
Enrollment: 500
Locations: 1
Primary Endpoint: enotyping for the SNP associated with liver cirrhosis
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee

Registry

clinicaltrials.gov

Start Date

March 30, 2022

End Date

January 20, 2023

Last Updated

3 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Asfendiyarov Kazakh National Medical University

Responsible Party

Principal Investigator

Ildar Fakhradiyev

Head of the Laboratory of Experimental Medicine

Asfendiyarov Kazakh National Medical University

Eligibility Criteria

Inclusion Criteria

•Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
•Representatives of the Kazakh ethnic group up to the 3rd generation;
•Hereditary history of arthrosis;
•Persons who are able and willing to provide written informed consent;

Exclusion Criteria

•Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
•Representatives of other ethnic groups;
•Representatives of the Kazakh ethnic group less than 3 generations;
•No family history of bilateral idiopathic gonarthrosis;
•Patients with an acute period of the inflammatory process (laboratory and clinical signs);
•Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
•Pregnant or lactating women;
•Tuberculosis of any localization in the active phase and in history;
•Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
•Severe and decompensated course of endocrine diseases;