NCT05095142已完成不适用
Preventive and Personalized Medicine (2021-2023)
Asfendiyarov Kazakh National Medical University1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2022年3月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- enotyping for the SNP associated with liver cirrhosis
研究概览
简要总结
The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 68 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
- •Representatives of the Kazakh ethnic group up to the 3rd generation;
- •Hereditary history of arthrosis;
- •Persons who are able and willing to provide written informed consent;
排除标准
- •Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
- •Representatives of other ethnic groups;
- •Representatives of the Kazakh ethnic group less than 3 generations;
- •No family history of bilateral idiopathic gonarthrosis;
- •Patients with an acute period of the inflammatory process (laboratory and clinical signs);
- •Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
- •Pregnant or lactating women;
- •Tuberculosis of any localization in the active phase and in history;
- •Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
- •Severe and decompensated course of endocrine diseases;
- •Autoimmune diseases;
- •Systemic diseases;
- •Oncological diseases;
结局指标
主要结局
enotyping for the SNP associated with liver cirrhosis
时间窗: 1 year
Genotype frequency of SNP in the study genes of participants and control participants.
次要结局
未报告次要终点
研究者
Ildar Fakhradiyev
Head of the Laboratory of Experimental Medicine
Asfendiyarov Kazakh National Medical University
研究点 (1)
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