The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 142
- 试验地点
- 1
- 主要终点
- Comparison of urinary BPA levels between the two groups
研究概览
简要总结
Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.
详细描述
71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function.
- •Normal group: thyroid autoantibody negative, normal thyroid function.
- •No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used.
排除标准
- •Patients with severe liver, kidney, heart and other important organ failure.
- •Merger with other autoimmune diseases.
- •Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.
结局指标
主要结局
Comparison of urinary BPA levels between the two groups
时间窗: 2019-2011
Urinary BPA levels were compared between patients with autoimmune thyroid disease and normal women.
Comparison of urinary iodine levels between the two groups
时间窗: 2019-2011
Urinary iodine levels were compared between patients with autoimmune thyroid disease and normal women.
次要结局
- Influencing factors of autoimmune thyroid diseases.(2019-2012)
研究者
Xiaomei Zhang
Director, Head of endocrinology department.
Peking University International Hospital