miRNA Biomarkers in Multiple Sclerosis
Completed
- Conditions
- miRNAMultiple SclerosisBiomarkerEpigenetic
- Registration Number
- NCT04772495
- Lead Sponsor
- University of Gaziantep
- Brief Summary
Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS). Recent studies have shown that dysregulated miRNAs alter immune responses, so they may have roles basis on various genetic diseases such as MS and may be potential targets for biomarkers and new therapeutic approaches. In this study, we evaluated the dysregulation of miRNA expression levels at MS and MS stages. We also discussed the potential of these miRNAs to be biomarkers and/or therapeutic targets in MS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 69
Inclusion Criteria
- The age of 25 years and above
- at least one Central Nervous System (CNS) demyelination event
Exclusion Criteria
- with genetic diseases, hypertension, head trauma, neuropsychiatric disease, diabetes mellitus, hypertension, cardiac failure, hepatic failure, renal failure, Thalassemia, Sickle cell disease, iron deficiency, and B12 deficiency
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method miRNA expression intraoperative peripheral blood miRNA expressions
- Secondary Outcome Measures
Name Time Method