A Phase II Trial of CyberKnife Radiosurgery to Perioptic Tumors
- Conditions
- Tumor, Benign, Optic Nerve
- Interventions
- Radiation: CyberKnife Radiosurgery
- Registration Number
- NCT02225197
- Lead Sponsor
- Community Cancer Center, Normal, Illinois
- Brief Summary
The purpose of this study is to find out what effects (good and bad) CyberKnife stereotactic radiosurgery has on tumors near the critical structures of the eye (optic apparatus).
The investigators hypothesize that hypofractionated stereotactic radiotherapy via the CyberKnife ® can deliver tumor ablating doses of radiation to perioptic lesions safely and effectively while sparing the adjacent optic apparatus and normal brain tissues from receiving damaging doses of radiation.
- Detailed Description
The CyberKnife system is a type of radiation machine that uses a special system to precisely focus large doses of x-rays (radiation) on the tumor. The device is designed to concentrate large doses of radiation onto the tumor so that injury from radiation to the nearby normal tissue will be minimal.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Perioptic lesion within 2mm of the optic apparatus
- Age >= 21
- KPS >= 50
- Planning Target Volume (PTV) <= 6.0 cm in maximal diameter
- Malignant histology
- Age < 21
- KPS <= 40
- Planning Target Volume (PTV) > 6.0 cm in maximal diameter
- Prior whole brain XRT
- Gross total resection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description CyberKnife Radiosurgery CyberKnife Radiosurgery -
- Primary Outcome Measures
Name Time Method Tumor status 5 years To determine the local control rate of patients with perioptic lesions treated with stereotactic CyberKnife radiosurgery.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Community Cancer Center
🇺🇸Normal, Illinois, United States